Natural Products Journal, The - Volume 12, Issue 5, 2022

Overexploitation of antibiotics has led to significant challenges with antimicrobial resistance. The gravity of this trend has resulted in the rapid emergence of multi-resistant pathogens. Increased frequency to treat infections and the unfeasibility to reverse this resistance have burdened researchers in developing novel mechanisms to counteract and obstruct antimicrobial resistance. An effective medical strategy to contr Read More

Podophyllotoxin is a nonalkaloid toxin aryltetralin lactone lignan, occurring naturally and extracted from the rhizomes and roots of Podophyllum species. Podophyllotoxin and its derivatives have been shown to possess a broad spectrum of pharmacological activities, mainly antineoplastic and antiviral properties. Podophyllotoxin serves as a potential anticancer agent and also the precursor for the chemical synthesis of some cli Read More

Background: Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred to as God’s crown, Mahkota dewa, Pau, grows all year long in tropical countries, including Malaysia, Indonesia, Papua New Guinea, and Australia. It is traditionally used to treat haemorrhoids, stroke, heart disease, tumour, impotence, diabetes, allergies, kidney and liver disorders, migraine, acne, and skin ailments. Objective: The purpose of Read More

Aim: The development of a suitable standardized Cyanthillium cinereum (L.) H.Rob. extract is an active ingredient in healthcare products. Background: C. cinereum is the herbal tea specified in the Thai National List of Essential (herbal) Medicines (NLEM) as the most efficacious tea for smoking cessation. However, herbal tea is inconvenient, and no standardized C. cinereum extraction method was known. Objectives: Th Read More

Background: Depression is common in hypertensive patients, and monotherapy may contribute to controlling depression in hypertensive patients and improving socioeconomic outcomes. Previous studies have shown that Acacia tortilis possesses hypotensive activity. Objectives: The present study was planned to evaluate the hemodynamic activity and antidepressant effects of an ethanolic extract of Acacia tortilis leaves (ATE Read More

Background: In recent years, the study of the structure and biological activity of medicinal plants has been particularly important to search for diabetes medicine. Ruellia tuberosa is used to treat various diseases such as diabetes by inhibiting the activity of α-glucosidase. Objective: In this study, an experiment was designed to isolatedisolate and identifiedidentifyα-glucosidase inhibitory extracts and compounds from Ruellia Read More

Background: Ischemia/reperfusion (I/R) injury is one of the major causes of mortality. I/R injury leads to apoptosis in the brain, especially in the hippocampus and induces cognitive impairments. On the other hand, Salvia officinalis L. is perennial, evergreen subshrub that is widely used in traditional medicine. The antiapoptosis and antioxidant effects of Salvia officinalis L. have also been reported. Objective: In this study, w Read More

Background: Adenocarpus complicatus L. is one of Adenocarpus genus, which has about 50 species, from Fabaceae (Papilionaceae) family. This plant is found in the Mediterranean basin as a southern west part of Europe and North Afric forestes. Objective: Isolation of Isocarpine From Adenocarpus Complicatus as Anticandidal Agent. Methods: A new piperidine alkaloid Isocarpine was isolated from the aerial parts of Ade Read More