The Multi Steps Synthetic Methods of (±)-Indolizidine 209D as an Amphibian Natural Product in the Family of Alkaloids

(±)-Indolizidine 209D is one of the alkaloids isolated from the skin secretions of certain neotropical frogs and exhibit a range of pharmacological properties, including blocking neuromuscular transmission. Therefore, the synthesis of indolizidine 209D and more complex derivatives, have been the subject of several publications. The preparation pathways of indolizidine 209D and its derivatives are the subject of this review. In this paper, some highly regio- and stereoselective functionalization process were reviewed through the synthesis of the optically active (±)-indolizidine 209D.