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Volume 5, Issue 1
  • ISSN: 0250-6882
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Abstract

The current treatments for bladder cancer are unable to substantially avoid the disease's growth and recurrence, which is a serious public health problem. Researchers have explored a variety of approaches in an effort to effectively replicate the pathophysiology of human tumors using experimental tumor models. The investigation of the available models is a necessary tool in order to choose the most appropriate scheme which serves the translation of potential treatments from a primary experimental bench to the clinical settings. The most suitable murine models of bladder cancer should have excellent reproductivity, intravesical predictability, and accessibility in order to facilitate the mechanistic, chemo-preventive, and therapeutic research that can be expanded into clinical trials. This article provides a complete evaluation of both and bladder cancer models, comparing their advantages and limitations in urological research.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-05-31

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/content/journals/nemj/10.2174/0250688204666230713093742
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Experimental Animal Models for Preclinical Investigation of the Bladder Cancer
NEW Emirates Medical J 5, e130723218679 (2024); https://doi.org/10.2174/0250688204666230713093742
/content/journals/nemj/10.2174/0250688204666230713093742
/content/journals/nemj/10.2174/0250688204666230713093742
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  • Article Type:     Review Article
Keyword(s): Animal models; Bladder cancer; Cancer cells; Implantation; Preclinical studies; Urological research

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