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Volume 4, Issue 2
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Background

S100B, NSE, MMP-9, and Tau protein levels increase in cases causing hypoxic cell damage. The diagnosis of the severity of carbon monoxide (CO) poisoning in the early period of these parameters was studied.

Materials and Methods

COHb level measurement was made using a signal capture CO-pulse oximeter (Masimo's SET Rainbow, Masimo's Co, USA) at the first admission of the patients. Then, COHb levels were confirmed by arterial blood gas(ABG) analysis. The patients were divided into two groups as mild and moderate-severe, according to their Glasgow coma scores (GCS) [Mild (14–15); Moderate (9–13) or Severe (3–8)]. The control group was composed of 16 healthy and non-smoking volunteers.

Results

The serum S100B protein and MMP-9 values at 0 hr of admission in the hospital and 3hr of treatment were not significantly different in the patient group as compared to the control group. Tau protein levels were significantly higher in the patient group at 0 and 3 hours (p> 0.05) as compared to healthy person.

Conclusion

There was no relationship between CO poisoning and MMP-9 and S100B protein levels. NSE and Tau protein were significantly higher in the patient group than the control group. Tau protein may be more useful marker as compared to neuron-specific enolase.

© 2023 Bentham Science Publishers
© 2023 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/nemj/10.2174/0250688204666230508115135
2023-07-18
2025-03-01

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/content/journals/nemj/10.2174/0250688204666230508115135
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Matrix Metalloproteinase-9, Neuron-specific Enolase, S100 B and Tau Protein Levels in the Patients with Carbon monoxide Poisoning
NEW Emirates Medical J 4, e080523216643 (2023); https://doi.org/10.2174/0250688204666230508115135
/content/journals/nemj/10.2174/0250688204666230508115135
/content/journals/nemj/10.2174/0250688204666230508115135
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  • Article Type:     Research Article
Keyword(s): Acute carbon monoxide; Carbon monoxide poisoning; Hypoxic cell damage; Matrix metalloproteinase 9; Patients; Tau protein

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