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Volume 2, Issue 1
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Post-transplant Lymphoproliferative Disorders (PTLD) are a well known late complication after solid organ transplantation, including renal transplant. Among others, graft failure due to reactivation of BK polyomavirus in the grafted kidney is also a well-recognized complication but tends to present early in the first several months after transplant.

Here we present the case of PTLD Burkitt's Lymphoma (BL-PTLD) in a renal transplant patient who was successfully treated with multiagent chemo-immunotherapy but later developed BK polyomavirus nephropathy (BKVN) with graft failure only after completion of her systemic therapy for lymphoma and 7 years after the transplant. Relevant literature is reviewed.

In this case, reactivation and progression of BKVN were most likely associated with immunosuppression from chemo-immunotherapy for her BL–PTLD, unlike early graft failures associated with BKVN.

© 2021 Bentham Science Publishers
© 2021 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/nemj/10.2174/0250688201999200520125625
2020-05-20
2025-03-13

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References

  1. EngelsE.A. PfeifferR.M. FraumeniJ.F.Jr KasiskeB.L. IsraniA.K. SnyderJ.J. WolfeR.A. GoodrichN.P. BayaklyA.R. ClarkeC.A. CopelandG. FinchJ.L. FleissnerM.L. GoodmanM.T. KahnA. KochL. LynchC.F. MadeleineM.M. PawlishK. RaoC. WilliamsM.A. CastensonD. CurryM. ParsonsR. FantG. LinM. Spectrum of cancer risk among US solid organ transplant recipients.JAMA2011306171891190110.1001/jama.2011.159222045767
     [Google Scholar]
  2. SiegelR.L. MillerK.D. JemalA. Cancer statistics, 2016.CA Cancer J. Clin.201666173010.3322/caac.2133226742998
     [Google Scholar]
  3. QuinlanS.C. PfeifferR.M. MortonL.M. EngelsE.A. Risk factors for early-onset and late-onset post-transplant lymphoproliferative disorder in kidney recipients in the United States.Am. J. Hematol.201186220620910.1002/ajh.2191121264909
     [Google Scholar]
  4. PAya CV, Fung JJ, Nalesnik MA, Kieff E, Green M, Gores G, habermann TM, Weisner PH, Swinnen JL, Woodle ES, Bromberg JS.Ebstein Barr virus induced post transplant lymphoproliferative disorders: AST S/AST P EBV–PTLD task force in the Mayo Clinic organized international consensus development meeting.Transplantation199968151725
     [Google Scholar]
  5. DierickxD HabermannTM Post transplant lymphoproliferative disorders in adults.NEJM2018378654962
     [Google Scholar]
  6. BobilloS. AbrisquetaP. Sánchez-GonzálezB. GinéE. RomeroS. AlcocebaM. González-BarcaE. González de VillambrosíaS. SanchoJ.M. GómezP. BentoL. MontoroJ. MontesS. LópezA. BoschF. (Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea (GEL/TAMO cooperative group).Post transplant monomorphic Burkitt’s lymphoma: Clinical characteristics and outcome of a multicentric series.Ann. Hematol.201897122417242410.1007/s00277‑018‑3473‑830116871
     [Google Scholar]
  7. MischitelliM. BellizziA. AnzivinoE. FioritiD. BoldoriniR. MiglioU. ChiariniF. Di MonacoF. PietropaoloV. Complications post renal transplantation: literature focus on BK virus nephropathy and diagnostic tools actually available.Virol. J.200853810.1186/1743‑422X‑5‑3818315864
     [Google Scholar]
  8. AmbalathingalG.R. FrancisR.S. SmythM.J. SmithC. KhannaR. BK polyoma virus: Clinical aspects, immune regulation and emerging therapies.Clin. Microbiol. Rev.201730250352810.1128/CMR.00074‑1628298471
     [Google Scholar]
  9. BabelN. VolkH.D. ReinkeP. BK polyomavirus infection and nephropathy: the virus-immune system interplay.Nat. Rev. Nephrol.20117739940610.1038/nrneph.2011.5921610680
     [Google Scholar]
  10. SharmaS.G. NickeleitV. HerlitzL.C. de GonzalezA.K. StokesM.B. SinghH.K. MarkowitzG.S. D’AgatiV.D. BK polyoma virus nephropathy in the native kidney.Nephrol. Dial. Transplant.201328362063110.1093/ndt/gfs53723249622
     [Google Scholar]
  11. PhamPT ReddyUG Immunosuppression and risk of polyoma virus BK replication.20139135136
     [Google Scholar]
/content/journals/nemj/10.2174/0250688201999200520125625
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BK Polyoma Virus Nephropathy in an Immunocompromised Host
NEW Emirates Medical J 2, 45 (2021); https://doi.org/10.2174/0250688201999200520125625
/content/journals/nemj/10.2174/0250688201999200520125625
/content/journals/nemj/10.2174/0250688201999200520125625
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  • Article Type:     Case Report
Keyword(s): BK polyomavirus nephropathy; Burkitt's Lymphoma; Chemo-immunotherapy; Immunosuppression; Lymphoproliferative disorders; PTLD

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