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Volume 5, Issue 1
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Introduction

Valvular heart diseases are some of the most common causes of cardiovascular morbidity and mortality worldwide. The mitral valve is estimated to be the cause of 15% of deaths in heart valve disease. Mitral valve dysfunction can be treated with a variety of operative options, one of which is mitral valve replacement. Although it is less desirable than repair, in some situations, it is the only viable option. Thus, we conducted this systematic review to help guide future risk assessment for mitral valve replacement patients and help in the construction of pre-operative risk assessment tools.

Methods

This is a systematic review of original articles discussing the topic of predictors of mortality for patients undergoing mitral valve replacement surgery. A systematic search was conducted independent researchers across a number of databases, starting with PubMed databases utilizing its MeSH database, followed by a complementary search through Google Scholar.

Results

In total, 27 original articles were included in a collective cohort of 145005 patients. Older age was the most commonly cited variable as a mortality predictor, followed by decreased left ventricular ejection fraction. EuroSCORE is a well-known scoring system that predicts in-hospital mortality following major cardiac surgeries. It was found that it overestimated mortality greatly, while another study found that the revised EuroSCORE II system was a better predictor of mortality. Overall, we note that both versions usually overestimate mortality.

Conclusion

There seems to be an overall agreement over several factors, including older age, decreased ejection fraction, and the expertise of the surgeon and the institution on being clear predictors of postoperative mortality. There is also an obvious need for new tools to better predict mortality rates preoperatively, as the currently used scores often result in greatly inaccurate predictions.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-07-11
2025-01-31

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References

  1. AluruJ.S. BarsoukA. SaginalaK. RawlaP. BarsoukA. Valvular heart disease epidemiology.Med. Sci.20221023210.3390/medsci1002003235736352
     [Google Scholar]
  2. O’DonnellA. YutzeyK.E. Mechanisms of heart valve development and disease.Development202014713dev18302010.1242/dev.18302032620577
     [Google Scholar]
  3. NkomoV.T. GardinJ.M. SkeltonT.N. GottdienerJ.S. ScottC.G. Enriquez-SaranoM. Burden of valvular heart diseases: A population-based study.Lancet200636895401005101110.1016/S0140‑6736(06)69208‑816980116
     [Google Scholar]
  4. SupinoP.G. BorerJ.S. PreibiszJ. BornsteinA. The epidemiology of valvular heart disease: A growing public health problem.Heart Fail. Clin.20062437939310.1016/j.hfc.2006.09.01017448426
     [Google Scholar]
  5. RajamannanN.M. GershB. BonowR.O. Calcific aortic stenosis: From bench to the bedside--emerging clinical and cellular concepts.Br. Heart J.200389780180510.1136/heart.89.7.80112807865
     [Google Scholar]
  6. BonowR.O. CarabelloB.A. ChatterjeeK. de LeonA.C.Jr FaxonD.P. FreedM.D. GaaschW.H. LytleB.W. NishimuraR.A. O’GaraP.T. O’RourkeR.A. OttoC.M. ShahP.M. ShanewiseJ.S. SmithS.C.Jr JacobsA.K. AdamsC.D. AndersonJ.L. AntmanE.M. FaxonD.P. FusterV. HalperinJ.L. HiratzkaL.F. HuntS.A. LytleB.W. NishimuraR. PageR.L. RiegelB. American College of Cardiology/American Heart Association Task Force on Practice Guidelines Society of Cardiovascular Anesthesiologists Society for Cardiovascular Angiography and Interventions Society of Thoracic Surgeons ACC/AHA 2006 guidelines for the management of patients with valvular heart disease.Circulation20061145e84e23110.1161/CIRCULATIONAHA.106.17685716880336
     [Google Scholar]
  7. McNeelyC. VassilevaC. Long-term outcomes of mitral valve repair versus replacement for degenerative disease: A systematic review.Curr. Cardiol. Rev.201411215716210.2174/1573403X1066614082709365025158683
     [Google Scholar]
  8. GammieJ.S. ChikweJ. BadhwarV. ThibaultD.P. VemulapalliS. ThouraniV.H. GillinovM. AdamsD.H. RankinJ.S. GhoreishiM. WangA. AilawadiG. JacobsJ.P. SuriR.M. BollingS.F. FosterN.W. QuinnR.W. Isolated mitral valve surgery: The society of thoracic surgeons adult cardiac surgery database analysis.Ann. Thorac. Surg.2018106371672710.1016/j.athoracsur.2018.03.08630032907
     [Google Scholar]
  9. LeeH.A. LinC.Y. ChenY.C. ChenS.W. NanY.Y. LiuK.S. WuM.Y. ChangY.S. ChuJ.J. LinP.J. TsaiF.C. Surgical interventions of isolated active mitral valve endocarditis.Medicine20189711e005410.1097/MD.000000000001005429538196
     [Google Scholar]
  10. PageM.J. McKenzieJ.E. BossuytP.M. BoutronI. HoffmannT.C. MulrowC.D. ShamseerL. TetzlaffJ.M. AklE.A. BrennanS.E. ChouR. GlanvilleJ. GrimshawJ.M. HróbjartssonA. LaluM.M. LiT. LoderE.W. Mayo-WilsonE. McDonaldS. McGuinnessL.A. StewartL.A. ThomasJ. TriccoA.C. WelchV.A. WhitingP. MoherD. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews.BMJ202137271n7110.1136/bmj.n7133782057
     [Google Scholar]
  11. VitelE. GalliE. LeclercqC. FournetM. BosseauC. CorbineauH. BouzilleG. DonalE. Right ventricular exercise contractile reserve and outcomes after early surgery for primary mitral regurgitation.Heart20181041085586010.1136/heartjnl‑2017‑31209729208632
     [Google Scholar]
  12. KimH.M. ChoG.Y. HwangI.C. ChoiH.M. ParkJ.B. YoonY.E. KimH.K. Myocardial strain in prediction of outcomes after surgery for severe mitral regurgitation.JACC Cardiovasc. Imaging20181191235124410.1016/j.jcmg.2018.03.01629778855
     [Google Scholar]
  13. AlkhouliM. RihalC.S. ZackC.J. EleidM.F. MaorE. SarrafM. CabalkaA.K. ReederG.S. HaglerD.J. MaaloufJ.F. NkomoV.T. SchaffH.V. SaidS.M. Transcatheter and surgical management of mitral paravalvular leak.JACC Cardiovasc. Interv.201710191946195610.1016/j.jcin.2017.07.04628982558
     [Google Scholar]
  14. IbrahimK.S. KheirallahK.A. MegdadiM.A. Enlargement of the left atrium strongly predicts postoperative mortality following heart valve surgery.Vasc. Health Risk Manag.20221878379110.2147/VHRM.S38046336212553
     [Google Scholar]
  15. Rzucidło-ResilJ. PlicnerD. GackowskiA. KapelakB. StolińskiJ. Impact of the mechanism of mitral regurgitation on clinical outcomes in patients after mitral valve surgery.Kardiol. Pol.201977552553410.5603/KP.a2019.004330835328
     [Google Scholar]
  16. KilicA. AckerM.A. GleasonT.G. SultanI. VemulapalliS. ThibaultD. AilawadiG. BadhwarV. ThouraniV. KilicA. Clinical outcomes of mitral valve reoperations in the United States: An analysis of the society of thoracic surgeons national database.Ann. Thorac. Surg.2019107375475910.1016/j.athoracsur.2018.08.08330365952
     [Google Scholar]
  17. WangT.K.M. HarmosS. GambleG.D. RamanathanT. RuygrokP.N. Performance of contemporary surgical risk scores for mitral valve surgery.J. Card. Surg.201732317217610.1111/jocs.1310728198037
     [Google Scholar]
  18. UdeshR. MehtaA. GleasonT.G. WechslerL. ThirumalaP.D. Perioperative strokes and early outcomes in mitral valve surgery: A nationwide analysis.J. Cardiothorac. Vasc. Anesth.201731252953610.1053/j.jvca.2016.12.00628259602
     [Google Scholar]
  19. Das DeS. NanjappaA. MorcosK. AftabS. ButlerJ. PathiV. CurryP. NairS. The effect of patient-prosthesis mismatch on survival after aortic and mitral valve replacement: A 10 year, single institution experience.J. Cardiothorac. Surg.201914121410.1186/s13019‑019‑1034‑431810475
     [Google Scholar]
  20. PerrottaS. FröjdV. LeporeV. ScherstenH. JeppssonA. SvenssonG. Surgical treatment for isolated mitral valve endocarditis: A 16-year single-centre experience.Eur. J. Cardiothorac. Surg.201853357658110.1093/ejcts/ezx41629186533
     [Google Scholar]
  21. TüysüzM.E. DedemoğluM. The effectiveness of heart valve replacement surgery in a non-referral regional hospital: The analysis of outcomes after isolated and complex valve replacement.Heart Surg. Forum2019225E343E35110.1532/hsf.237331596709
     [Google Scholar]
  22. AlkhouliM. AlqahtaniF. BerzingiC. CookC.C. Contemporary trends and outcomes of mitral valve surgery for infective endocarditis.J. Card. Surg.201934758359010.1111/jocs.1411631212382
     [Google Scholar]
  23. KoK. de KroonT.L. PostM.C. KelderJ.C. SchutK.F. SaoutiN. van PutteB.P. Minimally invasive mitral valve surgery: A systematic safety analysis.Open Heart202072e00139310.1136/openhrt‑2020‑00139333046594
     [Google Scholar]
  24. IyengarA. GoelN. KellyJ.J. HanJ. BrownC.R. KhurshanF. ChenZ. DesaiN. Effects of frailty on outcomes and 30-day readmissions after surgical mitral valve replacement.Ann. Thorac. Surg.202010941120112610.1016/j.athoracsur.2019.10.08732200907
     [Google Scholar]
  25. MehaffeyJ HawkinsR SchubertS FonnerC YarboroL QuaderM Contemporary outcomes in reoperative mitral valve surgery.Heart2018104865265610.1136/heartjnl‑2017‑312047
     [Google Scholar]
  26. CollinsN. SugitoS. DaviesA. BoyleA. SverdlovA. AttiaJ. StewartS. PlayfordD. StrangeG. Prevalence and survival associated with pulmonary hypertension after mitral valve replacement: National echocardiography database of Australia study.Pulm. Circ.2022124e1214010.1002/pul2.1214036262467
     [Google Scholar]
  27. PromratpanW. TheerasuwipakornN. LertsuwunseriV. SrimahachotaS. Long-term outcomes of severe rheumatic mitral stenosis after undergoing percutaneous mitral commissurotomy and mitral valve replacement: A 10-year experience.J. Cardiovasc. Thorac. Res.202214210110710.34172/jcvtr.2022.1635935386
     [Google Scholar]
  28. KitadaY. ArakawaM. OkamuraH. AkiyoshiK. HoriD. KimuraN. YamaguchiA. Impact of prosthesis-patient mismatch on late outcomes after bioprosthetic mitral valve replacement for mitral regurgitation.J. Artif. Organs202225213213910.1007/s10047‑021‑01299‑934665354
     [Google Scholar]
  29. ShiraziZ. ZiaK. MangiA.R. MinhajS. UtradiV.Sr BughioH. AchakzaiA. KarimM. RabbiF. ChaudryP.A. Common predisposing factors in mortality of patients after undergoing mitral valve surgery at a tertiary care hospital in Karachi.Cureus20201212e1196410.7759/cureus.1196433425540
     [Google Scholar]
  30. FarooqO. JanA. GhaniU. QaziU. Hassan KhanW. AlamS. KhanM.J. KhanO.A. AwanN.I. ShahH. Pulmonary hypertension as a predictor of early outcomes of mitral valve replacement: A study in rheumatic heart disease patients.Cureus20211312e2007010.7759/cureus.2007035003943
     [Google Scholar]
  31. JiangL. WeiX. HeP. FengD. LiuY. LiuJ. ChenJ. YuD. TanN. Value of pulmonary artery pressure in predicting in-hospital and one-year mortality after valve replacement surgery in middle-aged and aged patients with rheumatic mitral disease: An observational study.BMJ Open201775e01431610.1136/bmjopen‑2016‑01431628495812
     [Google Scholar]
  32. AkuffuA.M. ZhaoH. ZhengJ. NiY. Prosthesis-patient mismatch after mitral valve replacement: A single-centered retrospective analysis in East China.J. Cardiothorac. Surg.201813110010.1186/s13019‑018‑0788‑430285794
     [Google Scholar]
  33. ChivassoP. BrunoV.D. FaridS. MalvindiP.G. ModiA. BenedettoU. CiulliF. Abu-OmarY. CaputoM. AngeliniG.D. LiveseyS. VohraH.A. Predictors of survival in octogenarians after mitral valve surgery for degenerative disease: The mitral surgery in octogenarians study.J. Thorac. Cardiovasc. Surg.2018155414741482.e210.1016/j.jtcvs.2017.11.02729249501
     [Google Scholar]
  34. ElhenawyA.M. AlgarniK. RaoV. YauT.M. Predictors of hospital mortality after surgery for ischemic mitral regurgitation: The toronto general hospital experience.J. Card. Surg.202035123334333910.1111/jocs.1506432985733
     [Google Scholar]
  35. MoreiraJ.L. BarlettaP.H.A.A.S. BauciaJ.A. Morbidity and mortality in patients undergoing mitral valve replacement at a cardiovascular surgery referral service: A retrospective analysis.Rev. Bras. Cir. Cardiovasc.202136210.21470/1678‑9741‑2019‑0440
     [Google Scholar]
  36. MagantiK. RigolinV.H. SaranoM.E. BonowR.O. Valvular heart disease: Diagnosis and management.Mayo Clin. Proc.201085548350010.4065/mcp.2009.070620435842
     [Google Scholar]
  37. IungB. ArmoiryX. VahanianA. BoutitieF. MewtonN. TrochuJ.N. LefèvreT. Messika-ZeitounD. GuerinP. CormierB. BrochetE. ThibaultH. HimbertD. ThivoletS. LeurentG. BonnetG. DonalE. PiriouN. PiotC. HabibG. RouleauF. CarriéD. NejjariM. OhlmannP. Saint EtienneC. LerouxL. GilardM. SamsonG. RioufolG. Maucort-BoulchD. ObadiaJ.F. MITRA-FR Investigators Percutaneous repair or medical treatment for secondary mitral regurgitation: Outcomes at 2 years.Eur. J. Heart Fail.201921121619162710.1002/ejhf.161631476260
     [Google Scholar]
  38. StoneG.W. LindenfeldJ. AbrahamW.T. KarS. LimD.S. MishellJ.M. WhisenantB. GrayburnP.A. RinaldiM. KapadiaS.R. RajagopalV. SarembockI.J. BriekeA. MarxS.O. CohenD.J. WeissmanN.J. MackM.J. COAPT Investigators Transcatheter mitral-valve repair in patients with heart failure.N. Engl. J. Med.2018379242307231810.1056/NEJMoa180664030280640
     [Google Scholar]
  39. AndrásiT.B. GlückA.C. Ben TaiebO. TalipovI. AbudurehemanN. VolevskiL. VasiloiI. Outcome of surgery for ischemic mitral regurgitation depends on the type and timing of the coronary revascularization.J. Clin. Med.2023129318210.3390/jcm1209318237176621
     [Google Scholar]
  40. MickS.L. KeshavamurthyS. GillinovA.M. Mitral valve repair versus replacement.Ann. Cardiothorac. Surg.20154323023710.3978/j.issn.2225‑319X.2015.03.0126309824
     [Google Scholar]
  41. van der MerweJ. CasselmanF. Mitral valve replacement—current and future perspectives.Open J. Cardiovasc. Surg.2017910.1177/117906521771902328757798
     [Google Scholar]
  42. ShahS.N. SharmaS. Mitral Stenosis. StatPearls.Treasure Island, FLStatPearls Publishing2023
     [Google Scholar]
  43. HarbS.C. GriffinB.P. Mitral valve disease: A comprehensive review.Curr. Cardiol. Rep.20171987310.1007/s11886‑017‑0883‑528688022
     [Google Scholar]
  44. FishbeinG.A. FishbeinM.C. Mitral valve pathology.Curr. Cardiol. Rep.20192176110.1007/s11886‑019‑1145‑531123911
     [Google Scholar]
  45. BurtonL.V. BeierK. Papillary Muscle Rupture. StatPearls.Treasure Island, FLStatPearls Publishing2023
     [Google Scholar]
  46. DassC. KanmanthareddyA. Rheumatic Heart Disease. StatPearls.Treasure Island, FLStatPearls Publishing2023
     [Google Scholar]
  47. HartM.A. ShroffG.R. Infective endocarditis causing mitral valve stenosis – a rare but deadly complication: A case report.J. Med. Case Reports20171114410.1186/s13256‑017‑1197‑328209176
     [Google Scholar]
  48. TanakaK. OhtakiE. MatsumuraT. MisuK. TohbaruT. AsanoR. KitaharaK. UmemuraJ. SumiyoshiT. KasegawaH. HosodaS. Impact of a preoperative mitral regurgitation scoring system on outcome of surgical repair for mitral valve prolapse.Am. J. Cardiol.200392111306130910.1016/j.amjcard.2003.08.01214636908
     [Google Scholar]
  49. Tevaearai StahelH.T. KammermannA. GahlB. EnglbergerL. CarrelT.P. A simple preoperative score including the surgeon’s experience to predict the probability of a successful mitral valve repair.Interact. Cardiovasc. Thorac. Surg.201724684184710.1093/icvts/ivw34728369395
     [Google Scholar]
  50. PillutlaV. GoodwinT.J. TutungiE. GaoH. AlmeidaA. The use of a preoperative mitral valve model to guide mitral valve repair.Heart Lung Circ.202029111704171210.1016/j.hlc.2020.01.01832690360
     [Google Scholar]
  51. AmblerG. OmarR.Z. RoystonP. KinsmanR. KeoghB.E. TaylorK.M. Generic, simple risk stratification model for heart valve surgery.Circulation2005112222423110.1161/CIRCULATIONAHA.104.51504915998680
     [Google Scholar]
  52. ChitwoodW.R.Jr Robotic mitral valve surgery: Overview, methodology, results, and perspective.Ann. Cardiothorac. Surg.20165654455510.21037/acs.2016.03.1627942486
     [Google Scholar]
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Predictors of Mortality Following Mitral Valve Replacement: A Systematic Review
NEW Emirates Medical J 5, e02506882312599 (2024); https://doi.org/10.2174/0102506882312599240708105339
/content/journals/nemj/10.2174/0102506882312599240708105339
/content/journals/nemj/10.2174/0102506882312599240708105339
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PRISMA checklist is available as supplementary material on the publisher’s website along with the published article. Supplementary material is available on the publisher’s website along with the published article.

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  • Article Type:     Review Article
Keyword(s): Heart valve disease; Mitral valve; Mitral valve replacement; Mitral valve surgery; Valvular replacement; Valvular surgery

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