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Volume 5, Issue 1
  • ISSN: 0250-6882
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Abstract

Background

Tertiary hyperparathyroidism (THPT) is a well-known complication of end-stage kidney disease (ESKD), resulting from a loss of functional renal tissue with subsequent alterations in calcium and phosphate metabolism. Tertiary hyperparathyroidism reflects severe parathyroid hyperplasia with autonomous excessive secretion of parathyroid hormone (PTH) that is no longer responsive to the concentration of plasma calcium and leads to abnormal bone remodelling, soft tissue calcifications, vasculopathy, and other systemic complications.

Case Presentation

The authors, hereby, highlight varied presentations of tertiary hyperparathyroidism (THPT) by presenting 3 interesting cases, describing their clinical course and outcomes. Through sharing these experiences and insights, we hope to contribute to a better understanding of THPT and its optimal management in patients with ESKD.

Conclusion

THPT can have a significant impact on patient health and quality of life. Despite the widespread use of interventions, such as vitamin D analogues, calcimimetics and parathyroidectomy, THPT remains a significant clinical challenge for patients with ESKD.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-04-23

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/content/journals/nemj/10.2174/0102506882262902231020110030
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Tertiary Hyperparathyroidism and Extra Skeletal Calcification in End Stage Kidney Disease Patients: Case-series and Literature Review
NEW Emirates Medical J 5, e02506882262902 (2024); https://doi.org/10.2174/0102506882262902231020110030
/content/journals/nemj/10.2174/0102506882262902231020110030
/content/journals/nemj/10.2174/0102506882262902231020110030
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  • Article Type:     Case Report
Keyword(s): Brown tumour; Calciphylaxis; Dialysis; End-Stage Kidney Disease (ESKD); Parathyroid Hormone (PTH); Tertiary hyperparathyroidism (THPT)

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