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Volume 5, Issue 1
  • ISSN: 0250-6882
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Abstract

Periodontitis is an oral inflammatory disease possessing detrimental impacts on supporting tissue of teeth (like gingiva, periodontal ligament, and alveolar bone) and involves a great number of individuals all over the world. One of the appropriate ways to prevent this disease is to find related risk factors. According to reports, pregnancy complications can be associated with this oral disease; however, the possible mechanisms linking these two conditions have not been exactly determined. Hence, in this review, we summarize documents related to pregnancy complications and periodontitis with a mechanistic insight.

Literature on the relevant topic was searched from scientific databases, including Scopus, Google Scholar, and PubMed, in English, between 1996 and 2022.

Based on reports, pregnancy complications (premature labor, low weight at birth, and preeclampsia) can be related to periodontitis. This linkage can be mediated by inflammatory reactions, one of the main pathogenic mechanisms in periodontitis. Pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, have the ability to induce labor and fetal toxicity and finally create preterm labor and low weight at birth. Besides, these cytokines can potentiate chronic inflammatory responses in the fetal-maternal interface, impair placentation, and create endothelial dysfunction.

It seems that pro-inflammatory reactions, like secretion of TNF-α, IL-1β, and IL-6, can be a bridge for associating periodontitis and pregnancy complications. However, more studies with larger sample sizes are needed to support these findings.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2025-01-19

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References

  1. HajishengallisG. Periodontitis: From microbial immune subversion to systemic inflammation.Nat. Rev. Immunol.2015151304410.1038/nri378525534621
     [Google Scholar]
  2. Aref NezhadR. MotedayyenH. Roghani-ShahrakiH. Do cytokines associate periodontitis with metabolic disorders? an overview of current documents.Endocr. Metab. Immune Disord. Drug Targets202222777878610.2174/187153032266622011911202635043774
     [Google Scholar]
  3. LarvinH. KangJ. AggarwalV.R. PavittS. WuJ. Multimorbid disease trajectories for people with periodontitis.J. Clin. Periodontol.202148121587159610.1111/jcpe.1353634409647
     [Google Scholar]
  4. GasnerN.S. SchureR.S. Periodontal Disease.StatPearlsTreasure Island (FL)StatPearls Publishing2021
     [Google Scholar]
  5. SinhaS. SonooP. SiddharthaR. SinghS. SinghA. Effect of conventional periodontal treatment (Scaling and Root Planing) on Type-2 diabetic patient with moderate generalized chronic periodontitis: A clinical study.J. Pharm. Bioallied Sci.202113S570610.4103/jpbs.JPBS_692_2034447186
     [Google Scholar]
  6. YangB. PangX. LiZ. ChenZ. WangY. Immunomodulation in the treatment of periodontitis: Progress and perspectives.Front. Immunol.20211278137810.3389/fimmu.2021.78137834868054
     [Google Scholar]
  7. Van DykeT.E. SheileshD. Risk factors for periodontitis.J. Int. Acad. Periodontol.2005713715736889
     [Google Scholar]
  8. ArmitageG.C. Bi‐directional relationship between pregnancy and periodontal disease.Periodontol. 2000201361116017610.1111/j.1600‑0757.2011.00396.x23240948
     [Google Scholar]
  9. BobetsisY.A. BarrosS.P. OffenbacherS. Exploring the relationship between periodontal disease and pregnancy complications.J. Am. Dent. Assoc.2006S137S7S1310.14219/jada.archive.2006.040317012730
     [Google Scholar]
  10. VeldtmanG.R. ConnollyH.M. GroganM. AmmashN.M. WarnesC.A. Outcomes of pregnancy in women with tetralogy of fallot.J. Am. Coll. Cardiol.200444117418010.1016/j.jacc.2003.11.06715234429
     [Google Scholar]
  11. AliA. HadlichF. AbbasM.W. IqbalM.A. TesfayeD. BoumaG.J. WingerQ.A. PonsuksiliS. MicroRNA–mRNA networks in pregnancy complications: A comprehensive downstream analysis of potential biomarkers.Int. J. Mol. Sci.2021225231310.3390/ijms2205231333669156
     [Google Scholar]
  12. HajishengallisG. ChavakisT. LambrisJ.D. Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy.Periodontol. 20002020841143410.1111/prd.1233132844416
     [Google Scholar]
  13. AnandP.S. JadhavP. KamathK.P. KumarS.R. VijayalaxmiS. AnilS. A case‐control study on the association between periodontitis and coronavirus disease (COVID‐19).J. Periodontol.202293458459010.1002/JPER.21‑027234347879
     [Google Scholar]
  14. GravesD. Cytokines that promote periodontal tissue destruction.J. Periodontol.2008798S1585159110.1902/jop.2008.08018318673014
     [Google Scholar]
  15. GravesD.T. CochranD. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction.J. Periodontol.200374339140110.1902/jop.2003.74.3.39112710761
     [Google Scholar]
  16. SattariM. TaheriR.A. ArefNezhadR. MotedayyenH. The expression levels of MicroRNA-146a, RANKL and OPG after non-surgical periodontal treatment.BMC Oral Health202121152310.1186/s12903‑021‑01883‑833388028
     [Google Scholar]
  17. StashenkoP. DewhirstF.E. PerosW.J. KentR.L. AgoJ.M. Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption.J. Immunol.198713851464146810.4049/jimmunol.138.5.14643492553
     [Google Scholar]
  18. BrunettiG. ColucciS. PignataroP. CoricciatiM. MoriG. CirulliN. ZalloneA. GrassiF.R. GranoM. T cells support osteoclastogenesis in an in vitro model derived from human periodontitis patients.J. Periodontol.200576101675168010.1902/jop.2005.76.10.167516253089
     [Google Scholar]
  19. MotedayyenH. GhotlooS. SaffariM. SattariM. AmidR. Evaluation of microRNA‐146a and its targets in gingival tissues of patients with chronic periodontitis.J. Periodontol.201586121380138510.1902/jop.2015.15031926313020
     [Google Scholar]
  20. SimaC. ViniegraA. GlogauerM. Macrophage immunomodulation in chronic osteolytic diseases—the case of periodontitis.J. Leukoc. Biol.2019105347348710.1002/JLB.1RU0818‑310R30452781
     [Google Scholar]
  21. WangC GuanY YangJ Cytokines in the progression of pancreatic β-cell dysfunction.Int. J. Endocrinol.20102010515136
     [Google Scholar]
  22. WaddingtonR.J. MoseleyR. EmberyG. Periodontal disease mechanisms: Reactive oxygen species: A potential role in the pathogenesis of periodontal diseases.Oral Dis.20006313815110.1111/j.1601‑0825.2000.tb00325.x10822357
     [Google Scholar]
  23. ReiterR.J. TanD. BurkhardtS. Reactive oxygen and nitrogen species and cellular and organismal decline: Amelioration with melatonin.Mech. Ageing Dev.200212381007101910.1016/S0047‑6374(01)00384‑012044950
     [Google Scholar]
  24. BeltonM. BrilhaS. ManavakiR. MauriF. NijranK. HongY.T. PatelN.H. DembekM. TezeraL. GreenJ. MooresR. AigbirhioF. Al-NahhasA. FryerT.D. ElkingtonP.T. FriedlandJ.S. Hypoxia and tissue destruction in pulmonary TB.Thorax201671121145115310.1136/thoraxjnl‑2015‑20740227245780
     [Google Scholar]
  25. CurtisM.A. DiazP.I. Van DykeT.E. The role of the microbiota in periodontal disease.Periodontol. 20002020831142510.1111/prd.1229632385883
     [Google Scholar]
  26. UsuiM. OnizukaS. SatoT. KokabuS. AriyoshiW. NakashimaK. Mechanism of alveolar bone destruction in periodontitis — Periodontal bacteria and inflammation.Jpn. Dent. Sci. Rev.20215720120810.1016/j.jdsr.2021.09.00534703508
     [Google Scholar]
  27. SiqueiraJ.F.Jr Endodontic infections: Concepts, paradigms, and perspectives.Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.200294328129310.1067/moe.2002.12616312324780
     [Google Scholar]
  28. SiqueiraJ.F.Jr RôçasI.N. Bacterial pathogenesis and mediators in apical periodontitis.Braz. Dent. J.200718426728010.1590/S0103‑6440200700040000118278296
     [Google Scholar]
  29. RoganovićJ. PetrovićN. Clinical perspectives of non-coding RNA in oral inflammatory diseases and neuropathic pain: A narrative review.Int. J. Mol. Sci.20222315827810.3390/ijms2315827835955417
     [Google Scholar]
  30. ZiM.Y.H. LongoP.L. Bueno-SilvaB. MayerM.P.A. Mechanisms involved in the association between periodontitis and complications in pregnancy.Front. Public Health2015229010.3389/fpubh.2014.0029025688342
     [Google Scholar]
  31. RaghupathyR. Cytokines as key players in the pathophysiology of preeclampsia.Med. Princ. Pract.201322S181910.1159/00035420023949305
     [Google Scholar]
  32. MooreS. IdeM. CowardP.Y. RandhawaM. BorkowskaE. BaylisR. WilsonR.F. A prospective study to investigate the relationship between periodontal disease and adverse pregnancy outcome.Br. Dent. J.2004197525125810.1038/sj.bdj.481162015359324
     [Google Scholar]
  33. DavenportE.S. WilliamsC.E.C.S. SterneJ.A.C. MuradS. SivapathasundramV. CurtisM.A. Maternal periodontal disease and preterm low birthweight: case-control study.J. Dent. Res.200281531331810.1177/15440591020810050512097443
     [Google Scholar]
  34. MadianosP.N. BobetsisG.A. KinaneD.F. Is periodontitis associated with an increased risk of coronary heart disease and preterm and/or low birth weight births?J. Clin. Periodontol.200229s3Suppl. 3223610.1034/j.1600‑051X.29.s3.2.x12787204
     [Google Scholar]
  35. JeffcoatM.K. GeursN.C. ReddyM.S. CliverS.P. GoldenbergR.L. HauthJ.C. Periodontal infection and preterm birth.J. Am. Dent. Assoc.2001132787588010.14219/jada.archive.2001.029911480640
     [Google Scholar]
  36. OffenbacherS. KatzV. FertikG. CollinsJ. BoydD. MaynorG. McKaigR. BeckJ. Periodontal infection as a possible risk factor for preterm low birth weight.J. Periodontol.19966710S1103111310.1902/jop.1996.67.10s.1103
     [Google Scholar]
  37. LópezN.J. SmithP.C. GutierrezJ. Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease: A randomized controlled trial.J. Periodontol.200273891192410.1902/jop.2002.73.8.91112211502
     [Google Scholar]
  38. RomeroB.C. ChiquitoC.S. ElejaldeL.E. BernardoniC.B. Relationship between periodontal disease in pregnant women and the nutritional condition of their newborns.J. Periodontol.200273101177118310.1902/jop.2002.73.10.117712416776
     [Google Scholar]
  39. ZenclussenA.C. Adaptive immune responses during pregnancy.Am. J. Reprod. Immunol.201369429130310.1111/aji.1209723418773
     [Google Scholar]
  40. PiccinniM. ScalettiC. MaggiE. RomagnaniS. Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancy.J. Neuroimmunol.20001091303310.1016/S0165‑5728(00)00299‑X10969178
     [Google Scholar]
  41. ChaouatG. ZourbasS. OstojicS. Lappree-DelageG. DubanchetS. LedeeN. MartalJ. A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy.J. Reprod. Immunol.2002531-224125610.1016/S0165‑0378(01)00119‑X11730920
     [Google Scholar]
  42. HayashiC. GudinoC.V. GibsonF.C.III GencoC.A. REVIEW: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways.Mol. Oral Microbiol.201025530531610.1111/j.2041‑1014.2010.00582.x20883220
     [Google Scholar]
  43. ShigeruS. AkitoshiN. SubaruM-H. ShiozakiA. The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy.J. Reprod. Immunol.2008771142210.1016/j.jri.2007.04.00717561268
     [Google Scholar]
  44. ChallisJ.R. LockwoodC.J. MyattL. NormanJ.E. StraussJ.F.III PetragliaF. Inflammation and pregnancy.Reprod. Sci.200916220621510.1177/193371910832909519208789
     [Google Scholar]
  45. RaghupathyR. Pregnancy: Success and failure within the Th1/Th2/Th3 paradigm.Seminars in immunology.Elsevier2001
     [Google Scholar]
  46. LiuY.S. WuL. TongX.H. WuL.M. HeG.P. ZhouG.X. LuoL.H. LuanH.B. Study on the relationship between Th17 cells and unexplained recurrent spontaneous abortion.Am. J. Reprod. Immunol.201165550351110.1111/j.1600‑0897.2010.00921.x21029245
     [Google Scholar]
  47. RobertsonS.A. PrinsJ.R. SharkeyD.J. MoldenhauerL.M. Seminal fluid and the generation of regulatory T cells for embryo implantation.Am. J. Reprod. Immunol.201369431533010.1111/aji.1210723480148
     [Google Scholar]
  48. ParthibanP. MahendraJ. Toll-Like Receptors: A Key Marker for Periodontal Disease and Preterm Birth – A Contemporary Review.J. Clin. Diagn. Res.201599ZE14ZE1710.7860/JCDR/2015/14143.652626501032
     [Google Scholar]
  49. SainiR. SainiS. SainiS. Periodontitis: A risk for delivery of premature labor and low birth weight infants.J. Nat. Sci. Biol. Med.201121505210.4103/0976‑9668.8232122470234
     [Google Scholar]
  50. ParkJ.S. ParkC.W. LockwoodC.J. NorwitzE.R. Role of cytokines in preterm labor and birth.Minerva Ginecol.200557434936616170281
     [Google Scholar]
  51. Arriaga-PizanoL. Jimenez-ZamudioL. Vadillo-OrtegaF. Martinez-FloresA. Herrerias-CanedoT. Hernandez-GuerreroC. The predominant Th1 cytokine profile in maternal plasma of preeclamptic women is not reflected in the choriodecidual and fetal compartments.J. Soc. Gynecol. Investig.200512533534210.1016/j.jsgi.2005.02.00515979545
     [Google Scholar]
  52. KaushicC. The role of the local microenvironment in regulating susceptibility and immune responses to sexually transmitted viruses in the female genital tract.J. Reprod. Immunol.2009831-216817210.1016/j.jri.2009.08.01019857903
     [Google Scholar]
  53. VickersN.J. Animal communication: When i’m calling you, will you answer too?Curr. Biol.20172714R713R71510.1016/j.cub.2017.05.06428743020
     [Google Scholar]
  54. MokeemS.A. MollaG.N. Al-JewairT.S. The prevalence and relationship between periodontal disease and pre-term low birth weight infants at King Khalid University Hospital in Riyadh, Saudi Arabia.J. Contemp. Dent. Pract.200452405610.5005/jcdp‑5‑2‑4015150633
     [Google Scholar]
  55. HuckO TenenbaumH DavideauJ-L Relationship between periodontal diseases and preterm birth: Recent epidemiological and biological data.Int J Appl Basic Med Res.2011512610.1155/2011/164654
     [Google Scholar]
  56. LeongX-F NgC-Y BadiahB DasS Association between hypertension and periodontitis: Possible mechanisms.Sci. World J.2014201476823710.1155/2014/768237
     [Google Scholar]
  57. DhadseP. GattaniD. MishraR. The link between periodontal disease and cardiovascular disease: How far we have come in last two decades?J. Indian Soc. Periodontol.201014314815410.4103/0972‑124X.7590821760667
     [Google Scholar]
/content/journals/nemj/10.2174/0102506882262319231213115239
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Pro-inflammatory Cytokines may Associate Periodontitis with Pregnancy Complications: A Short Review
NEW Emirates Medical J 5, e02506882262319 (2024); https://doi.org/10.2174/0102506882262319231213115239
/content/journals/nemj/10.2174/0102506882262319231213115239
/content/journals/nemj/10.2174/0102506882262319231213115239
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  • Article Type:     Review Article
Keyword(s): Gingiva; Oral inflammatory disease; Pathogenesis; Periodontitis; Pregnancy complications; Pro-inflammatory cytokines

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