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Mini Reviews in Medicinal Chemistry - Online First
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The Application of the Pyrazole Structure in the Structural Modification of Natural Products
Authors: Fu-Qun Sun, Ya-Lan Wang, Ke Sun, Fei-Xia Yue, Yun-Xia Sun, Jia-Hong Ju, Zhan-Hui Jin, Qing-Kun Shen, Hong-Yan Guo, Mei-Hui Liu and Zhe-Shan QuanAvailable online: 21 January 2025More LessMost natural products in nature have broad but not exceedingly good biological activities. The pyrazole structure has been introduced into natural products due to its suitability for various synthetic methods and its broad pharmacological activities. This article provides a detailed introduction to the anti-inflammatory, antibacterial, antifungal, antiviral, and anti-Alzheimer disease activities of pyrazole-modified natural product deri Read More
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Sustainable Synthesis of Medicinally Important Heterocycles
Authors: Dripta De Joarder, Rajarshi Sarkar and Dilip K. MaitiAvailable online: 16 January 2025More LessSustainable chemistry and nature-friendly protocols are not only luxury but has become essential requirement for the modern society as it progresses towards a more responsible future. To match the current needs of the community, industries and in particular chemical industry is looking for novel and cheap strategies that have less adverse effects on the environment. Heterocyclic compounds are one particular m Read More
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Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities
Authors: Melford Chuka Egbujor, Paolo Tucci and Luciano SasoAvailable online: 13 January 2025More LessCurrently, the synthesis of bioactive sulfonamides using amino acid as a starting reagent has become an area of research interest in organic chemistry. Over the years, an amine-sulfonyl chloride reaction has been adopted as a common step in traditional sulfonamide synthetic methods. However, recent developments have shown amino acids to be better precursors than amines in the synthesis of sulfonamides. Although Read More
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Recent Development in Hydantoins, Thiohydantoins, and Selenohydantoins as Anticancer Agents: Structure-activity Relationship and Design Strategies
Authors: Ajay Kumar Gupta, Gajendra Singh Thakur and Sanmati Kumar JainAvailable online: 10 January 2025More LessHydantoin, a five-membered heterocyclic scaffold, is regarded as a crucial scaffold in medicinal chemistry. Hydantoins have been useful in synthesizing medicines like nilutamide, enzalutamide, and apalutamide. Thiohydantoin and selenohydantoin have been discovered as two separate types of hydantoin. There are two hydrogen bond donors, two hydrogen bond acceptors, and four substitution sites. These characteristi Read More
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Promising Inhibitors of Endocannabinoid Degrading Enzymes Sharing a Carbamate Scaffold
Authors: Shivani Jaiswal and Senthil Raja AyyannanAvailable online: 25 November 2024More LessCarbamate has been extensively used as a scaffold in the recent era of drug discovery and is a common structural motif of many approved drugs. The carbamate moiety's unique amide-ester hybrid (-O-CO-NH-) feature offers the designing of specific drug-target interactions. Despite the discovery of numerous carbamate derivatives that act on the endocannabinoid system (ECS), the development of clinically effective car Read More
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Olaparib: A Chemosensitizer for the Treatment of Glioblastoma
Authors: Naresh Dhanavath, Priya Bisht, Mohini Santosh Jamadade, Krishna Murti, Pranay Wal, and and Nitesh KumarAvailable online: 22 October 2024More LessGlioblastoma (GBM) is the most prevalent and deadly primary brain tumor. The current treatment for GBM includes adjuvant chemotherapy with temozolomide (TMZ), radiation therapy, and surgical tumor excision. There is still an issue because 50% of patients with GBM who get TMZ have low survival rates due to TMZ resistance. The activation of several DNA repair mechanisms, such as Base Excision Repair (BER), DNA Mis Read More
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