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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System
- Source: Mini Reviews in Medicinal Chemistry, Volume 1, Issue 1, May 2001, p. 5 - 16
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- 01 May 2001
Abstract
TNF alpha is an inflammatory mediator that is relevant to several autoimmune diseases. Macromolecular inhibitors of TNF alpha have proven therapeutically useful in some preliminary studies. We have developed small molecule TNF alpha antagonist based on the crystal structure of TNF receptor complex. The TNF alpha inhibitor is specific and mediates biological function similar to the inhibitory soluble TNF receptor. This review focuses on development of small molecule anti-TNF alpha mimetics by us and current status of other agents.
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