Drug Delivery Letters - Volume 4, Issue 2, 2014

Albendazole, an anthelmintic drug belonging to BCS class II, has poor bioavailability. Bioavailability is dissolution rate dependent and hence needs novel approach for enhancement of bioavailability. The aim of the study was to develop nanosuspension of albendazole by using various techniques like nanoprecipitation, emulsion template and sonication. Nanosuspensions were prepared using polyvinylpyrrolidone K30 as a stabilizer Read More

For many years, improvements have been made in certain attempts for liposomal stability, by several methods, including preparing more stable bi-layers, coating their surface with protecting polymers, and modifying charge. These methods on subjecting to certain changes have led to a novel type of liposomes called proliposomes. Dry, free-flowing particles with a dispersed system that can form a liposomal suspension immedi Read More

The present research work was aimed to design the transdermal delivery system of naproxen using Aloe vera as aqueous gel base. Aloe vera would able to potentiate the anti-inflammatory effect and also act as penetration enhancer. Carbopol 934 was used as a gelling agent. The prepared gel was assessed for pH, permeation parameters, drug content, skin irritation and in-vitro diffusion. Accelerated stability study Read More

Cancer is one of the major causes of the death worldwide and its prevalence is expected to reach about 27 million by 2050 due to aging, adoption of cancer causing behaviours and limitations of cancer treatment. The major therapeutic approach for the treatment of cancer is chemotherapy but most chemotherapeutic agents experience some limitations including poor aqueous solubility, systemic toxicities and drug resistanc Read More

Cinnarizine pediatric preparation is extemporaneously prepared from adult tablets or capsules that are unstable in liquid dosage form. The aim of this work is to develop cinnarizine oral pediatric formulation with improved stability and organoleptic properties as well as to achieve ease of administration. For this purpose, cinnarizine-loaded microspheres of chitosan cross-linked with tripolyphosphate anion were prepared. A Read More

Synthetic DNA molecules of 10-23 deoxyribozymes (Dz) are known to be efficient and site-specific agents for the RNA cleavage in a catalytic manner. To provide the penetration of Dz into cells, we have proposed the new delivery system for deoxyribozymes in the form of TiO2•PL-Dz nanocomposite. These nanocomposites consist of catalytically active Dz molecules noncovalently immobilized through the polylysine link Read More

Minoxidil loaded nanosponges (NS) based hydrogel system was developed for topical application on to the scalp in order to avoid the disadvantages associated with the Minoxidil topical solution. The objective of this work was to formulate, characterize and evaluate hydrogel system bearing minoxidil loaded nanosponges. Nanosponges were developed using solvent evaporation method by reacting β-cyclodextrin with a cross l Read More

With the development of nanotechnology different biological nanomaterials have been developed, out of these, Carbon Nanotubes (CNTs) have attracted attention of various scientists as a carrier for the delivery of therapeutic agents. CNTs are third allotropic form of carbon-fullerenes which consist of graphite sheet rolled up into a cylindrical tube. They have nanometer scale diameter with high aspect ratio. CNTs exist in two f Read More

Quetiapine fumarate (QF) is an atypical antipsychotic, undergoing extensive first pass metabolism and hence shows lower bioavailability orally. Solid Lipid Nanoparticles (SLNs) of QF were developed using lipid dynasan 114 and surfactant poloxamer 188 and 407 by double microemulsion-solvent evaporation technique. The aim of this study was to develop and evaluate SLNs of QF for enhancement of bioavailability via oral route. Read More