Drug Delivery Letters - Volume 4, Issue 3, 2014

This recent research work was aimed to develop the oral dissolving films of gliclazide. Solid dispersions of gliclazide using natural polymers such as hupu gum (HG), guar gum (GG) and xanthan gum (XG) were prepared by kneading technique and the optimized solid dispersion was exploited to develop the gliclazide films. Different grades of HPMC (E5, 50 cps and K4M) were used to develop the films by adapting solvent casting Read More

Cystic fibrosis (CF), a genetic lethal chronic disease, causes the body to produce abnormally thick and sticky mucus. As a consequence following bacterial infections threaten ten thousands of people around the world every year. Available tests enable early diagnosis of CF. Nevertheless, current treatments can only serve to improve patient’s quality of life. Despite the fact that life span of CF patients is dramatically increas Read More

Amphotericin B (Amb) is a broad-spectrum polyene macrolide antibiotic which has been a drug of choice for fatal conditions like fungal splenic abscess. Hence a drug delivery system with splenotropic potencial might be of great significance for further therapeutic effectiveness. Present manuscript proposes development of Irregular shaped polymer lipid hybrid nanostructures (LIPOMER) of Amb with enhanced splenic upt Read More

The objective of the present study was to formulate bilayer matrix tablets containing aceclofenac as sustained release and paracetamol as immediate release using HPMC as the matrix forming polymer and the tablets were evaluated via in-vitro studies. In-vitro drug release studies were carried out in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The amount of drugs released at di Read More

In the present work, an attempt was made to develop and evaluate composite microspheres for controlled release of an anti-diabetic drug, nateglinide (NTG). The composite microspheres were prepared using rosin gum and ethyl cellulose as retardant polymers for drug release by solvent evaporation method. DSC and XRD analysis indicated the uniform dispersion of drug in the microspheres. The microspheres wer Read More

The effect of stainless steel microneedle arrays and rollers on transcutaneous flux of captopril and metoprolol tartrate across full thickness porcine skin was studied. Captopril is an angiotensin converting enzyme (ACE) inhibitor used for the management of hypertension. It has a partition coefficient (log P) of 0.35 and a molecular weight of 216.7 g/mol. Metoprolol tartrate is a β-adrenergic blocker also used for the manage Read More

Nowadays natural or herbal products are more often used in comparison to synthetic products because of their low toxicity, biodegradability, biocompatibility and cheaper cost. An effort has been made to design and characterize buccal films of glimepiride using natural polymer. The natural polymer was extracted from Trigonella foenumgraecum L(Methi) seed. The polymer was extracted by solvent extraction method Read More

Dissolution of drug from solid dosage form is explained by kinetic models i.e. zero order, first order, higuchi model, Hixson-crowell cube root law, Korsmeyer-peppas and weibull model. These models are effective as design of new delivery device and the existing device is optimized by these models. In this study, these models are classified on two different bases. All these models are explained including their kinetic equations, Read More