Drug Delivery Letters - Volume 4, Issue 1, 2014

Advances in strategies for treating a wide variety of diseases require an efficient delivery of the active compounds into the cytosol of target cells. One of the challenges for the efficient intracellular delivery of therapeutic biomolecules after their cell internalization by endocytosis is to manipulate or circumvent the non-productive trafficking from endosomes to lysosomes, where degradation may occur. Because the na Read More

Administration of drugs is often associated with basic problems such as toxicity, instability and improper biodistribution. Encapsulation of the drug in a suitable carrier such as liposomes is one of the well recognized methods that protects the drug from the body milieu to improve stability, safety and targeting efficiency of the drug towards the target site. However, while encapsulation provides a favorable biodistribution, low toxici Read More

Milnacipran hydrochloride (MIL) is a selective serotonin and norepinephrine dual reuptake inhibitor used for the treatment of depression and fibromyalgia. The aim of present work was to carry out comparative pharmacokinetics evaluation of in-house developed oral controlled release (CR) and marketed immediate release (IR) tablet formulation of MIL. Three prototype CR formulations (i) MIL with HPMC 100K, single hy Read More

During the past 20 years, advances in drug formulations and innovative routes of administration have been made. The understanding of drug transport across tissues has increased. The administration of drug by transmucosal routes offers the advantage of being a relatively painless administration and has the potential for greater flexibility in a variety of clinical situations. The transmucosal route includes oral, nasal, v Read More

Colorectal cancer being a life style disease, number of cases is increasing day by day. Oral drug delivery to treat colonic diseases encounters many problems like drug stability in the harsh environment of the upper GI tract, low percentage of drug remained in the dosage form to be released in the colon, heavy dilution of the drug released in the colon fluid etc. Hence novel strategies for colon targeting has attracted significant a Read More

Oral fast dissolving films have carved a niche in the pharmaceutical industry and are giving a competitive edge as compared to other dosage forms as an innovative drug delivery. Pfizer introduced Listerine melt in mouth pocket packs to overcome the limitations of other dosage forms. Since then a large number of pharmaceutical industries are casting light upon this drug delivery with attributing to its major contribution in the Read More

Novel drug delivery systems (NDDS) delivered the active molecules to the target site in a defined manner for produce the desired effects without disturbing the delicate bio-environment. Among many available colloidal drug delivery systems, Liposomes (a class based on phospholipids) have attracted more attention than other systems due to many meritorious features such as excellent chemical & biological stability, good sol Read More

In research and development (R & D) sector, scientific and technical developments are ready for the expansion of oral drug delivery systems. The medicated chewing gum (MCG) takes accumulative approval as a drug delivery system in pharmaceutical as well as clinical fields. It offers advantages both for (a) local treatment and (b) systemic effect after absorption through the buccal, sublingual mucosal and from the ga Read More

The objective of the present study is to elaborate a new approach for drug loading into electrospun nanofibers through active loading based on non-solvent evaporation technique. The polymeric nanofibers were achieved by electrospinning method using PCL, PVA and a blend of sodium alginate & PVA as polymeric constituents. Different methods such as passive & active (solvent and non-solvent evaporation methods) tec Read More