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2000
Volume 11, Issue 6
  • ISSN: 2215-0838
  • E-ISSN: 2215-0846
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Abstract

Background

Diabetes Mellitus is a global health concern affecting millions of individuals worldwide. It is characterized by hyperglycemia resulting from insufficient insulin production or insulin resistance. Its high prevalence, especially in developing countries, such as Pakistan, demands effective and economically viable treatments.

Objectives

The objective of this study was to identify herbal remedies for effectively targeting gluconeogenic enzymes in the treatment of diabetes mellitus. It aimed to explore herbal remedies for providing cost-effective alternatives with lesser side effects for the treatment of diabetes by targeting gluconeogenic enzymes.

Methods

The proteins of the already-known diabetic herb (Bitter melon) were initially investigated through molecular docking. Then, the proteins similar to the best-docked protein of Momordica Charactia were identified, and their molecular docking analysis was performed.

Results

The results showed three plants having similar proteins to the best-docked protein, namely (sponge gourd), (cucumber), and (Pumpkin). The molecular docking analysis of these proteins revealed (Cucumber) as a potential herbal candidate for the treatment of diabetes mellitus.

Conclusion

The results of this study highlight the potential of (Cucumber) for treating diabetes mellitus by targeting gluconeogenic enzymes. However, further research is necessary regarding the therapeutic potential of cucumber.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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References

  1. BandayM.Z. SameerA.S. NissarS. Pathophysiology of diabetes: An overview.Avicenna J. Med.202010417418810.4103/ajm.ajm_53_20 33437689
     [Google Scholar]
  2. LinX. XuY. PanX. Global, regional, and national burden and trend of diabetes in 195 countries and territories: An analysis from 1990 to 2025.Sci. Rep.20201011479010.1038/s41598‑020‑71908‑9 32901098
     [Google Scholar]
  3. AzeemS. KhanU. LiaquatA. The increasing rate of diabetes in Pakistan: A silent killer.Ann. Med. Surg. (Lond.)20227910390110.1016/j.amsu.2022.103901
     [Google Scholar]
  4. FurmanB.L. CandasamyM. BhattamisraS.K. VeettilS.K. Reduction of blood glucose by plant extracts and their use in the treatment of diabetes mellitus; discrepancies in effectiveness between animal and human studies.J. Ethnopharmacol.202024711226410.1016/j.jep.2019.112264 31600561
     [Google Scholar]
  5. MaK. ZhouL. ZhangY. Efficacy and safety of traditional Chinese medicines combined with conventional Western medicines in the treatment of type 2 diabetes mellitus: A network meta-analysis of randomized controlled trials.Front. Endocrinol. (Lausanne)202314113429710.3389/fendo.2023.1134297 37223050
     [Google Scholar]
  6. JiangS. YoungJ. WangK. QianY. CaiL. Diabetic induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus.(Review)Mol. Med. Rep.202022260361110.3892/mmr.2020.11175 32468027
     [Google Scholar]
  7. Galicia-GarciaU. Benito-VicenteA. JebariS. Pathophysiology of Type 2 Diabetes Mellitus.Int. J. Mol. Sci.20202117627510.3390/ijms21176275 32872570
     [Google Scholar]
  8. ChakrabortyA.J. UddinT.M. Matin ZidanB.M.R. Allium cepa: A treasure of bioactive phytochemicals with prospective health benefits.Evid. Based Complement. Alternat. Med.2022202212710.1155/2022/4586318 35087593
     [Google Scholar]
  9. XieC. GaoW. LiX. LuoS. WuD. ChyeF.Y. Garlic (Allium sativum L.) polysaccharide ameliorates type 2 diabetes mellitus (T2DM) via the regulation of hepatic glycogen metabolism.NFS J.202331192710.1016/j.nfs.2023.02.004
     [Google Scholar]
  10. RichterE. GeethaT. BurnettD. BroderickT.L. BabuJ.R. The effects of Momordica charantia on Type 2 diabetes mellitus and Alzheimer’s Disease.Int. J. Mol. Sci.2023245464310.3390/ijms24054643 36902074
     [Google Scholar]
  11. Muñiz-RamirezA. PerezR.M. GarciaE. GarciaF.E. Antidiabetic activity of Aloe vera leaves.Evid. Based Complement. Alternat. Med.202020201910.1155/2020/6371201 32565868
     [Google Scholar]
  12. SuwannapongA. TalubmookC. PrompromW. Evaluation of antidiabetic and antioxidant activities of fruit pulp extracts of Cucurbita moschata Duchesne and Cucurbita maxima Duchesne.Scientific World Journal2023202311210.1155/2023/1124606 37398913
     [Google Scholar]
  13. AlkreathyH.M. AhmadA. Catharanthus roseus combined with ursolic acid attenuates streptozotocin-induced diabetes through insulin secretion and glycogen storage.Oxid. Med. Cell. Longev.202020201810.1155/2020/8565760 32148658
     [Google Scholar]
  14. TranN. PhamB. LeL. Bioactive compounds in anti-diabetic plants: From herbal medicine to modern drug discovery.Biology (Basel)20209925210.3390/biology9090252 32872226
     [Google Scholar]
  15. LiuZ. GongJ. HuangW. LuF. DongH. The effect of Momordica charantia in the treatment of diabetes mellitus: A review.Evid. Based Complement. Alternat. Med.20212021379626510.1155/2021/3796265
     [Google Scholar]
  16. PirovichD.B. Da’daraA.A. SkellyP.J. Multifunctional fructose 1,6-bisphosphate aldolase as a therapeutic target.Front. Mol. Biosci.2021871967810.3389/fmolb.2021.719678 34458323
     [Google Scholar]
  17. YuS. MengS. XiangM. MaH. Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis.Mol. Metab.20215310125710.1016/j.molmet.2021.101257 34020084
     [Google Scholar]
  18. ShahA. WondisfordF.E. Gluconeogenesis flux in metabolic disease.Annu. Rev. Nutr.202343115317710.1146/annurev‑nutr‑061121‑091507 37603427
     [Google Scholar]
  19. Huerta-ReyesM. Tavera-HernándezR. Alvarado-SansinineaJ.J. Jiménez-EstradaM. Selected species of the cucurbitaceae family used in mexico for the treatment of diabetes mellitus.Molecules20222711344010.3390/molecules27113440 35684376
     [Google Scholar]
  20. LotfiM. BehpoorN. RahimiM. JafariA. Separate and combined effects of resistance training and cucumber (Cucumis sativus) juice consumption on the diabetic indicators and lipid profile in women with type 2 diabetes.Majallah-i Danishgah-i Ulum-i Pizishki-i Kirmanshah2023272e13785610.5812/jkums‑137856
     [Google Scholar]
  21. SahaiV. KumarV. Antidiabetic, antihyperlipidemic, antioxidant, hepatoprotective and renal protective effect of luffa cylindrica extract against the streptozotocin-induced diabetes mellitus in rats.Int. J. Pharm. Sci. Res.20231441872188610.13040/ijpsr.0975‑8232.14(4).1872‑86
     [Google Scholar]
/content/journals/ctm/10.2174/0122150838299329240425071320
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Molecular Docking Analysis of Herbal Medicines for the Treatment of Diabetes Mellitus
Current Traditional Medicine 11, E22150838299329 (2025); https://doi.org/10.2174/0122150838299329240425071320
/content/journals/ctm/10.2174/0122150838299329240425071320
/content/journals/ctm/10.2174/0122150838299329240425071320
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  • Article Type:     Research Article
Keyword(s): cucumis sativus; Diabetes mellitus; gluconeogenic enzymes; herbal remedies; molecular docking; momordica charantia

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