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image of Molecular Docking Analysis of Herbal Medicines for Diabetes Mellitus Treatment

Abstract

Background

Diabetes Mellitus is a global health concern affecting millions of individuals worldwide. It is characterized by hyperglycemia resulting from insufficient insulin production or insulin resistance. Its high prevalence, especially in developing countries, such as Pakistan, demands effective and economically viable treatments.

Objectives

The objective of this study was to identify herbal remedies for effectively targeting gluconeogenic enzymes in the treatment of diabetes mellitus. It aimed to explore herbal remedies for providing cost-effective alternatives with lesser side effects for the treatment of diabetes by targeting gluconeogenic enzymes.

Methods

The proteins of the already-known diabetic herb (Bitter melon) were initially investigated through molecular docking. Then, the proteins similar to the best-docked protein of Momordica Charactia were identified, and their molecular docking analysis was performed.

Results

The results showed three plants having similar proteins to the best-docked protein, namely (sponge gourd), (cucumber), and Cucurbita Maxima (Pumpkin). The molecular docking analysis of these proteins revealed Cucumis Sativus (Cucumber) as a potential herbal candidate for the treatment of diabetes mellitus.

Conclusion

The results of this study highlight the potential of (Cucumber) for treating diabetes mellitus by targeting gluconeogenic enzymes. However, further research is necessary regarding the therapeutic potential of cucumber.

© 2024 Bentham Science Publishers
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2024-11-29
2025-01-22

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Molecular Docking Analysis of Herbal Medicines for Diabetes Mellitus Treatment
Bentham Science Publishers ; https://doi.org/10.2174/0122150838299329240425071320
/content/journals/ctm/10.2174/0122150838299329240425071320
/content/journals/ctm/10.2174/0122150838299329240425071320
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  • Article Type:     Research Article
Keywords: herbal remedies ; gluconeogenic enzymes ; Diabetes mellitus ; molecular docking ; cucumis sativus ; momordica charantia

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