Current Signal Transduction Therapy - Current Issue

BackgroundHIV/AIDS remains a global health challenge, demanding innovative antiretroviral strategies. HIV integrase inhibition, a promising therapeutic target, warrants exploration. This study investigates the potential of Cryptolepine and analogues as integrase inhibitors through in-silico docking and ADMET profiles. Docking simulations reveal binding affinities, guiding rational drug design. ADMET predictions assess the ph Read More

IntroductionPeroxisome Proliferator-Activated Receptors (PPARs) are nuclear receptors involved in the regulation of glucose and lipid metabolism, making them potential targets for treating type 2 diabetes mellitus. 5-Benzylthiazolidine-2, 4-dione derivatives, organic compounds with a thiazolidine-2, 4-dione core and a benzyl moiety at the 5-position, have garnered attention for their diverse pharmacological activities, in Read More

Transcription factor PPAR-γ is predominantly found in adipose tissue, liver, and brain. PPARs form heterodimers, interact with ligands, and regulate the expression of the genes of the PPAR-γ downstream regulatory pathways. PPAR-γ is critical in regulating many physiological processes, including adipogenesis, glucose metabolism, fatty acid metabolism, energy homeostasis, and inflammation. This review is on the functions of PPA Read More

Current investigations have proposed that focusing on malignancy cell metabolism is an elective restorative methodology in cancer treatment. AMPK is the significant energy sensor regulating ordinary as well as malignancy cell metabolism. Drugs as AMPK activators can quell malignancy cell development through the various signalling cascade. AMPK enactment in light of natural AMPK activators, for example, BME, ICT, Th Read More