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Revisiting the Significance of TLRs: Current Understanding and Future Scope for Therapeutic Implications
Authors: Shiva Singh and Anuradha MishraAvailable online: 03 December 2024More LessPattern Recognition Receptors (PRRs), particularly Toll-Like Receptors (TLRs), are pivotal in the innate immune system for recognizing Pathogen-Associated Molecular Patterns (PAMPs) and initiating inflammatory responses. TLRs, characterized by their transmembrane structure, Leucine-Rich Repeat (LRR) ectodomain, and Toll/Interleukin-1 Receptor (TIR) domains, detect a diverse range of microbial and endogenous ligands thr Read More
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In silico ADMET and Molecular Docking Studies of Natural Analogues as AKT Inhibitors
Authors: Jasmeen Kaur, Amir Raza, Rajeev Gupta, Shivam Kumar Singh, Iqubal Brar and Pankaj WadhwaAvailable online: 11 November 2024More LessBackground AKT inhibition presents a promising avenue for cancer treatment strategies. By exploring natural analogues using in-silico docking and ADMET profiles, this work aims to design effective anti-cancer therapies shown by binding affinities and pharmacokinetic assessments. Aims and Objectives The aim of this research paper is to utilize in-silico ADMET profiling and molecular docking studies to investigate the potential Read More
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