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- Volume 20, Issue 1, 2025
Current Reviews in Clinical and Experimental Pharmacology - Volume 20, Issue 1, 2025
Volume 20, Issue 1, 2025
- Pharmacology
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Targeting SIRT1 by Scopoletin to Inhibit XBB.1.5 COVID-19 Life Cycle
More LessNatural products have historically driven pharmaceutical discovery, but their reliance has diminished with synthetic drugs. Approximately 35% of medicines originate from natural products. Scopoletin, a natural coumarin compound found in herbs, exhibits antioxidant, hepatoprotective, antiviral, and antimicrobial properties through diverse intracellular signaling mechanisms. Furthermore, it also enhances the activit Read More
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Translational Approach using Advanced Therapy Medicinal Products for Huntington's Disease
More LessCurrent therapeutic approaches for Huntington's disease (HD) focus on symptomatic treatment. Therefore, the unavailability of efficient disease-modifying medicines is a significant challenge. Regarding the molecular etiology, targeting the mutant gene or advanced translational steps could be considered promising strategies. The evidence in gene therapy suggests various molecular techniques, including knocking down mHT Read More
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- Pharmacology
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Anatomy, Etiology, Management, and Medico-Legal Implications of Botulinum-induced Blepharoptosis
More LessAuthors: Giulio Nittari, Demetris Savva, Filippo Gibelli, Diana Vulcanescu, Domenico De Leo and Giovanna RicciBotulinum toxin injections, a popular aesthetic treatment, have over 7.4 million beneficiaries in the U.S. Despite their safety record, these injections pose potential complications. It is essential for aesthetic practitioners to manage these complications with the least impact on the patient. Upper eyelid ptosis, though rare, is a significant side effect of botulinum toxin injections. Through our study, we have identif Read More
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Efficacy and Safety of Glycopyrrolate in the Management of Organophosphate and Carbamate Poisoning: A Systematic Review
More LessObjectiveThere is a lack of evidence on the effectiveness of antidotes in the management of organophosphate and carbamate (OPC) poisoning. We aimed to review the efficacy and safety of glycopyrrolate in the management of OPC poisoning.MethodologyDatabases such as PubMed, Scopus, Embase, and Cochrane Library were extensively searched from inception to November 2022 and updated till October 2023. Intervention Read More
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Cell-Derived Allograft Models as a Solution to the Obstacles of Preclinical Studies under Limited Resources: A Systematic Review on Experimental Lung Cancer Animal Models
More LessBackgroundThe use of appropriate animal models for cancer studies is a major challenge, particularly for investigators who lack the resources to maintain and use xenograft animals or genetically engineered mouse models (GEMM). In addition, several countries intending to incorporate these models must conduct importation procedures, posing an additional challenge.ObjectiveThis review aimed to explore the use of cell-deriv Read More
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The Association between use of Renin-Angiotensin-Aldosterone System Inhibitors and the Risk and Mortality of Pancreatic Cancer: A Systematic Review and Meta-Analysis
More LessBackgroundPancreatic Cancer (PC) is one of the most malignant tumors and highly invasive neoplasms around the world.ObjectiveThis systematic review and meta-analysis aims to study the relationship between the use of renin-angiotensin-aldosterone system inhibitors and the incidence and mortality of PC.MethodsThe electronic search was conducted systematically until October 10, 2023. in databases, including Scopus, Web Read More
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The Effect of Dapagliflozin on Heart Function in Animal Models of Cardiac Ischemia, A Systematic Review and Meta-analysis
More LessAuthors: Tina Kianfar, Raquibul Hasan, Yaser Azizi and Fatemeh RamezaniIntroductionIn this study, a meta-analysis was conducted to investigate the therapeutic effect of Dapagliflozin (DAPA) on animals suffering from myocardial ischemia reperfusion compared to the group that did not receive treatment.MethodsAccording to the inclusion and exclusion criteria two researchers performed the primary and secondary screening based on the title abstract and full text. After data extraction, meta-a Read More
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