Current Reviews in Clinical and Experimental Pharmacology - Volume 19, Issue 1, 2024

Background: Ruta graveolens L. belongs to Rutaceae; it is a semi-wood perennial or a small evergreen sub-shrub, which is native to Southern Europe, West Asia and Northern Africa.Objective: The goal of this manuscript was to outline the most notable traditional and modern advantages and pharmaceutical benefits of common rue.Methods: The manuscript covers review articles, randomized control experiments, analytic Read More

Background: Since their inception, preclinical experimental models have played an important role in investigating and characterizing disease pathogenesis. These in vivo, ex vivo, and in vitro preclinical tests also aid in identifying targets, evaluating potential therapeutic drugs, and validating treatment protocols.Introduction: Diarrhea is a leading cause of mortality and morbidity, particularly among children in develo Read More

Vaccines are important to improve immunity against pathogens and diseases. The current COVID-19 disease is rapidly evolving and spreading among people; therefore, it is important to utilize a proper vaccination strategy against it. Currently, many approved vaccines are available and accessible; however, there is a reported hesitancy against taking them among the public and even the health care workers. Mainly, this i Read More

Background: Dental implants have been one of the most popular treatments for rehabilitating individuals with single missing teeth or fully edentulous jaws since their introduction. As more implant patients are well-aged and take several medications due to various systemic conditions, clinicians should take into consideration the possible drug implications on bone remodeling and osseointegration.Objective: The present Read More

Opioids administered into the spinal space by intrathecal or epidural routes can provide potent and prolonged selective analgesia. Compared to the systemic administration of opioids, spinal administration can bring about analgesia with fewer central and systemic adverse effects. For the past 40 years, spinal opioid analgesia has achieved great popularity in various fields of pain treatment. The aim of this work is to identify clinical Read More

Background: Acanthamoeba is one of the opportunistic parasites with a global prevalence. Currently, due to the side effects and the emergence of drug resistance to this parasite, much research has been performed on the use of nano-drugs to treat Acanthamoeba-caused diseases. Therefore, this systematic review study aims to evaluate new strategies for treating diseases caused by Acanthamoeba based on nanoparticles (NP Read More

Background: Many medications have different pharmacokinetics in children than in adults. Knowledge about the safety and efficacy of medications in children requires research into the pharmacokinetic profiles of children's medicines. By analysing registered clinical trial records, this study determined how frequently pharmacokinetic data is gathered in paediatric drug trials.Methods: We searched for the pharmacokinetic da Read More

Objective: To determine the efficacy of the first triple CFTR protein modulators in children and adolescents with cystic fibrosis.Methods: Systematic review and meta-analysis were conducted, following PRISMA guidelines. The following databases were searched extensively: PubMed/Medline, Clinical trials.gov, Google Scholar, Scopus, Embase, and Europe PMC using the keywords: “Ivacaftor”, “Elexacaftor”, “Tezacaftor”, VX_66 Read More

Background: Urinary tract infections (UTIs) are the most prevalent bacterial infections that occur in children worldwide.Objective: This meta-analysis aims to investigate the utility of probiotics as preventive therapy in children with a UTI.Methods: The Web of Science, PubMed, and Scopus were searched for articles that investigated the relationship between probiotic consumption and the risk of UTIs. The quality of the articl Read More