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Protein Misfolding and Aggregation of Pathological Igg Light Chains in Oncohematological Dyscrasias: From Molecular Pathways to Clinical Implications
Authors: Tomáš Guman, Ján Sýkora, Veronika Demčáková and Gabriel ŽoldákAvailable online: 02 January 2025More LessNeoplastic transformation of B cells of the post-germinative center can lead to oncohematological dyscrasias, which often results in an abnormal production of monoclonal immunoglobulin light chains. The non-physiological production of large amounts of IgG light chains leads to the formation of extracellular deposits called 'aggregomas' and rare conditions such as light chain crystal deposition disease. Kidney manifestations an Read More
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Insight of Intestinal Fatty Acid Binding Protein as a Potential Biomarker in the Biology of Epithelial Damage of Gastrointestinal Membrane
Authors: Nahid Rehman and Anjana PandeyAvailable online: 01 January 2025More LessThe diagnosis of intestinal injury remains a challenge as it is rare in occurrence and transpires in multiple traumatized patients. The deferred finding of injury of intestines upsurges multiple risks such as septicemia, numerous organ failures as well as mortality. In this review, we corroborate with the goals of proposing surrogate biomarkers that consent to the measurement of the permeability of intestines more e Read More
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PPA1, TRIM68 and FBXO46: Potential Therapeutic Targets for Triple Negative Breast Cancer
Authors: Fatima Haider, Nida Syed, Syeda Abiha Zehra Jaffari, Basir Syed, Aftab Ahmed, Shamshad Zarina and Zehra HashimAvailable online: 01 January 2025More LessBackground Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high recurrence rate. A new therapeutic intervention is urgently needed to combat this lethal subtype. The identification of biomarkers is also crucial for improving outcomes in TNBC. Method The cell cytotoxicity of ML364 (2-(4-Methylphenylsulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide) was meas Read More
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Comparative Proteomic Analysis of Cell Wall Proteins of Aminoglycosides Resistant and Sensitive Mycobacterium tuberculosis Clinical Isolates
Authors: Devesh Sharma, Sakshi Gautam, Nalini Srivastava, Abdul Mabood Khan and Deepa BishtAvailable online: 07 November 2024More LessIntroduction The rising prevalence of Mycobacterium tuberculosis (M.tb) strains resistant to aminoglycosides (amikacin and kanamycin) challenges effective TB control and treatment. Understanding the mechanisms behind this resistance is crucial since aminoglycosides are a mainstay of TB therapy. Aim The study aimed to analyze the cell wall proteins overexpressed in aminoglycoside-resistant isolates of Mycobacterium tub Read More
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Myotoxicity of Crotoxin on C2C12 Myoblasts and its Inhibition by Crotalus Neutralizing Factor versus Enhanced Resistance in Myotubes: Exploring Toxicity and Membrane Potential
Authors: Maria Naiara Macedo Tavares, Micaela de Melo Cordeiro Eulálio, Hallison Mota Santana, Charles Nunes Boeno, Valdison Pereira dos Reis, Cristina Matiele Alves Rego, Alex Augusto Ferreira e Ferreira, Mauro Valentino Paloschi, Andreimar M. Soares, Consuelo Latorre Fortes-Dias, Sulamita Silva Setúbal and Juliana Pavan ZulianiAvailable online: 05 November 2024More LessBackground Crotalus Neutralizing Factor (CNF) is a γ-type Phospholipase A2 (PLA2) inhibitor present in the blood of Crotalus durissus terrificus snake. Particularly, CNF inhibits the toxic action of Crotoxin (CTX), which is a major neurotoxin found in C. d. terrificus venom. CTX induces also myotoxic action and demonstrates high selectivity for skeletal muscle fibers. Consequently, CTX can diffuse beyond the site of infection, Read More
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A Study on the Rationality of Baicalein in the Treatment of Osteoporosis: A Narrative Review
Authors: Qi Li, Xingyan Ma, Xiaodong Xu, Chengming Zhang and Weiguo WangAvailable online: 25 October 2024More LessBaicalein (BN) is an active ingredient naturally present in Chinese herbs, such as Scutellaria baicalein, Coptis chinensis, and Dendrobium officinale. It has a variety of pharmacological activities, including antioxidant, anti-inflammatory and antibacterial effects. Therefore, Baicalein (BN) is widely used in the field of medicine and is considered a potential natural medicine. Osteoporosis (OP) is a bone metabolic disease characterize Read More
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