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- Volume 22, Issue 19, 2016
Current Pharmaceutical Design - Volume 22, Issue 19, 2016
Volume 22, Issue 19, 2016
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The Production of Solid Dosage Forms from Non-Degradable Polymers
Authors: Ian Major, Evert Fuenmayor and Christopher McConvilleNon-degradable polymers have an important function in medicine. Solid dosage forms for longer term implantation require to be constructed from materials that will not degrade or erode over time and also offer the utmost biocompatibility and biostability. This review details the three most important non-degradable polymers for the production of solid dosage forms – silicone elastomer, ethylene vinyl acetate and thermopla Read More
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Polymer Particulates in Drug Delivery
Authors: Harmeet Kaur, Virender Kumar, Krishan Kumar, Sandeep Rathor, Parveen Kumari and Jasbir SinghDevelopment of effective drug delivery systems is important for medicine and healthcare. Polymer particulates (micro- and nanoparticles) have opened new opportunities in the field of drug delivery by overcoming various limitations of conventional delivery methods. The properties of polymeric particles can be readily tuned by precisely engineering the constituent blocks of polymers for improving drug loading, release Read More
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Polymer Self-Assembled Nanostructures as Innovative Drug Nanocarrier Platforms
Authors: Natassa Pippa, Stergios Pispas and Costas DemetzosBackground: Polymer self-assembled nanostructures are used in pharmaceutical sciences as bioactive molecules’ delivery systems for therapeutic and diagnostic purposes. Micelles, polyelectrolyte complexes, polymersomes, polymeric nanoparticles, nanogels and polymer grafted liposomes represent delivery vehicles that are marketed and/or under clinical development, as drug formulations. Methods: In this mini-review, the Read More
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Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review
Authors: Rafeeq Tanbour, Ana M. Martins, William G. Pitt and Ghaleb A. HusseiniBackground: Anti-neoplastic drugs used for cancer treatment often produce damage to healthy cells, leading to severe side effects in patients undergoing chemotherapy. The encapsulation of these agents in nanoparticles reduces the adverse side effects of conventional chemotherapy on healthy tissues. Such nanoparticles, considered as drug delivery vehicles, are diverse and include micelles, liposomes, dendrimers, nano Read More
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Hypoxia Responsive Drug Delivery Systems in Tumor Therapy
Hypoxia is a common characteristic of solid tumors. It is mainly determined by low levels of oxygen resulting from imperfect vascular networks supplying most tumors. In an attempt to improve the present chemotherapeutic treatment and reduce associated side effects, several prodrug strategies have been introduced to achieve hypoxia-specific delivery of cytotoxic anticancer agents. With the advances in nanotechnolo Read More
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Polymer Drug Conjugates: Recent Advancements in Various Diseases
Authors: Jasbir Singh, Sapna Desai, Snehlata Yadav, Balasubramanian Narasimhan and Harmeet KaurDuring the past decade, the arena of polymer therapeutics has acquired considerable interest and accompanied by advanced designs and chemical properties of polymer-drug conjugates. Various polymers, such as poly (ethylene glycol) (PEG), N-(2-hydroxypropyl) methacrylamide (HPMA), poly(glycolic acid) (PGA) and poly(lactide-co-glycolide) (PLGA) have been used successfully for clinical utilization from decades. Read More
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Perspectives of Engineered Marine Derived Polymers for Biomedical Nanoparticles
Authors: Khanh Thi My Tran, Toi Van Vo, Wei Duan, Phuong Ha-Lien Tran and Thao Truong-Dinh TranMarine environment exhibits an enormous diversity of organisms which contains an abundant source of polysaccharides. As polymer matrix carriers, marine-based polymers possess several valuable properties including high stability, non-toxicity, hydrophilicity, biodegradability, with low production cost. Despite notable biological activities of these natural polymers, there are certain limitations in exploring their functions i Read More
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Nanoscale Polymersomes as Anti-Cancer Drug Carriers Applied for Pharmaceutical Delivery
Authors: Ruslan G. Tuguntaev, Chukwunweike Ikechukwu Okeke, Jing Xu, Chan Li, Paul C. Wang and Xing-Jie LiangPolymersomes are self-assembled nano-vesicles composed of amphiphilic block copolymers. These building blocks can be selected from a large number of hydrophilic and hydrophobic polymers in order to achieve required properties of the final system, such as biodegradability, sustainable and multiple stimuli-response drug release, long blood circulation, and low toxicity. Moreover, the surface of polymersomes can be funct Read More
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Converting Human Proteins into Precision Polymer Therapeutics
Authors: Felix Boldt, Weina Liu, Yuzhou Wu and Tanja WeilCells as the smallest unit of life rely on precise macromolecules and programmable supramolecular interactions to accomplish the various vital functions. To translate such strategies to precisely control architectures and interactions into the synthetic world represents an exciting endeavor. Polymers with distinct structures, sequences and architectures are still challenging to achieve. However, in particular for biomedical appl Read More
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Polymeric Based Therapeutic Delivery Systems Prepared Using Electrohydrodynamic Processes
Authors: M. Rasekh, K. Nazari, M.S. Arshad, I. Kucuk, R. Haj-Ahmad, A. Hussain, M.A. Morris, N. Abbas, M.-W. Chang, X. Li and Z. AhmadThe development of therapeutic dosage (e.g. pharmaceutical) systems is an ongoing process which, in recent times has incorporated several emerging disciplines and themes at timely intervals. While the concepts surrounding dosage forms have developed and evolved, many polymeric excipients remain as the preferred choice of materials over existing counterparts, serving functions as matrix materials, coatings and pr Read More
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Polymer-Based Drug Delivery Systems, Development and Pre-Clinical Status
Background: The nanomedicine is considered as the application of nanotechnology in the medical field where nanoparticles are sized in the nanoscale range. Drug delivery technologies are becoming increasingly important as a scientific area of investigation. Controlled-release systems and drug-targeting systems represents an alternative to traditional delivery nanoparticles, and the use of polymers is increasing nowada Read More
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Nanoparticulate Drug Delivery to Colorectal Cancer: Formulation Strategies and Surface Engineering
Authors: Thao Truong-Dinh Tran, Phuong Ha-Lien Tran, Yichao Wang, Puwang Li and Lingxue KongThe evolution of polymer-based nanoparticle as a drug delivery carrier has greatly contributed to the development of advanced nano and micro-medicine in the past few decades. The polymer-based nanoparticles of biodegradable and biocompatible polymers such as poly (lactide-co-glycolide) and chitosan which have been approved by Food & Drug Administration and/or European Medicine Agency can particularly fac Read More
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Drug Delivery to CNS: Challenges and Opportunities with Emphasis on Biomaterials Based Drug Delivery Strategies
Authors: Ekta Khambhla, Viral Shah and Kalpesh BaviskarThe current epoch has witnessed a lifestyle impregnated with stress, which is a major cause of several neurological disorders. High morbidity and mortality rate due to neurological diseases and disorders have generated a huge social impact. Despite voluminous research, patients suffering from fatal and/or debilitating CNS diseases such as brain tumors, HIV, encephalopathy, Alzheimer’s, epilepsy, Parkinson’s, migraine and Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 41
- Issue 42
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 33
- Issue 3
- Issue 2
- Issue 1
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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