Current Proteomics - Volume 18, Issue 3, 2021

A proteome is an efficient rendition of a genome, unswervingly controlling various cancer processes. Molecular mechanisms of several cancer processes have been unraveled by the proteomic approach. Thus far, numerous tumors of diverse status have been investigated by two-dimensional electrophoresis. Numerous biomarkers have been recognized and precise categorization of apparent lesions has led to the Read More

Background: The current study was undertaken with a major goal of evaluating the influence of the heavy metal Copper (Cu) on growth and physiology as well as the proteomic status of Ziziphus spina-christi. Objective: We set a hypothesis that Z. spina-christi could be a potent phytoremediator in Cu-polluted environments and the industrial area of Riyadh was chosen as a model of contaminated sites. Methods: Read More

Background: Salinity is a major abiotic stress that limits plant growth and development. Salinity affects several physiological and biochemical characteristics adversely, which results in oxidative stress in plant species. Plants change the protein pattern to cope with salinity stress. The identified salt-responsive proteins in alfalfa are involved in energy and metabolism, photosynthesis, regulation of carbohydrates, transcri Read More

Background: Cancer is a genetic disorder in which several factors like oncoviruses are involved. Among viruses, Human T-lymphotropic virus 1 (HTLV-1) is a human oncovirus whose long-term infection leads to Adult T-Cell Leukemia/Lymphoma (ATLL). The lack of a vaccine against HTLV-1 and limited efficacy of available treatments for ATLL due to the weakness of the immune system led us to develop novel therapeutic\pro Read More

Aim: Molecular cloning and analysis of Pectin Iyase (PNL) genes from different strains of Fusarium for structural predictions and docking studies. Background: PNLs cleave pectin by β-elimination resulting in the formation of 4,5-unsaturated oligogalacturonates, without affecting the ester content of the polymer chain and hence maintaining the specific aroma of fruits. Several PNL lyase genes from Aspergillus and Penicilliu Read More

Background: CCl4 Acute Liver Injury (ALI) is a classical model for experimental research. However, there are few reports involved in the fundamental research of CCl4-induced ALI. Ligustri Lucidi Fructus (LLF) and its prescription have been used to treat hepatitis illness clinically. LLF and its active ingredients displayed anti-hepatitis effects, but the mechanism of . function has not yet been fully clarified. Objective: To in Read More

Background: Amyloids are a class of ordered protein aggregates which have been implicated in the onset of several degenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Type II diabetes, and so on. Despite extensive research, the exact mechanism and the driving factors for the amyloidogenesis process remain elusive. Identifying molecules which can effectively inhibit and/or disaggregate the fibrils may be o Read More

Background: “Angiogenesis”, a major oncogenic signaling pathway, has been termed to be the most fascinating area of cancer therapy. Viewing this, the molecular chaperone Hsp90 has surfaced as a potential molecular target due to being vitally engrossed in sustaining stability, integrity, and functions of crucial proteins involved in multiple signaling pathways of tumor progression and metastasis. Objective: The study set si Read More

Background: Haptoglobin (Hp), an acute-phase protein, is known as a potential diagnostic biomarker in human diseases. Two alleles of Hp (Hp1 and Hp2 ) exist in humans allowing three phenotypes (Hp1-1, Hp2-1, and Hp2-2), which influence the biophysical and biological properties of Hp. Objective: This work aimed to investigate the variation of serum level and fucosylation change among Hp phenotypes in patients with lu Read More

Background: Escherichia coli host has been the workhorse for the production of heterologous proteins due to simplicity of use, low cost, availability of various expression vectors, and a plethora of knowledge on its genetic characteristics, but without a suitable signal sequence, this host cannot be used for the production of secretory proteins. Humulin is a form of insulin used to treat hyperglycemia caused by types 1 and 2 diabetes Read More

Aims: This study aimed to perform a quantitative analysis of the proteomic changes in neural cells under H2O2 exposure and N-acetylcysteine (NAC) treatment. Background: NAC is a potent antioxidant and an effective free radical scavenger that has been used as a potential treatment of several neurological disorders. Although the molecular mechanisms of neuroprotective action by NAC have been studied, more efforts a Read More

Background: The human serotonin transporter is an important drug target for the treatment of various medical conditions of which depression is the most important, but also include attention deficit hyperactivity disorder, schizophrenia, social anxiety disorder and irritable bowel syndrome, among others. The transmembrane portion of the human transporter has been studied extensively and was first crystalized in 2016. Ho Read More

Aim: The purpose of this study was to conduct in silico analysis of the Lampyroidea maculata luciferase enzyme. Background: Bioluminescence is the production and emission of light by the luciferase enzymes in a living organism. The luciferase enzyme has been widely used in biotechnology due to its excellent properties. Objective: Recently, the new gene of the luciferase from the Lampyroidea maculata, has been cloned an Read More