Current Proteomics - Volume 18, Issue 1, 2021

Aim: The purpose of this study was to screen the bacteria producing cellulase enzymes and their bioinformatics studies. Background: Cellulose is a long-chain polymer of glucose that hydrolyzes by cellulases to glucose molecules. In order to design the new biotechnological applications, some strategies have been used as increasing the efficiency of enzyme production, generating cost-effective enzymes, producing stable enzy Read More

Background: Mycobacterium tuberculosis (MTB) and Mycobacterium avium (MA) are intracellular parasitic bacteria. The biological characteristics of MA and MTB are very similar and need to be identified. Objective: The study aims to better understand how MTB survives in macrophages and the different pathogenic mechanisms of MTB and MA. Methods: The Tandem Mass Tag (TMT) and liquid chromatography-tandem mass spect Read More

Background: Glycation is a nonenzymatic post-translational modification process by attaching a sugar molecule to a protein or lipid molecule. It may impair the function and change the characteristic of the proteins which may lead to some metabolic diseases. In order to understand the underlying molecular mechanisms of glycation, computational prediction methods have been developed because of their convenience a Read More

Background: Moyamoya Disease (MMD) is a rare cerebrovascular disease with a high rate of disability and mortality. Immune reactions have been implicated in the pathogenesis of MMD, however, the underlying mechanism is still unclear. Objective: To identify proteins related to MMD specially involved in the immunogenesis, we performed a proteomic study. Methods: In this work, dural tissues or plasma from 98 patients with M Read More

Background: The cellular antiviral responses induced by interferons require some cellular protein kinase for its activation. Evidence indicated that a number of Hepatitis C Virus (HCV) proteins can repress double-stranded (ds) RNA-dependent Protein Kinase (PKR) function and help HCV to escape. However, the reports are controversial, some researchers have suggested that a region in Nonstructural 5A (NS5A) gene called Protein Read More

Aim: We aimed to identify new plasma biomarkers for the diagnosis of Pulmonary Tuberculosis (PTB). Background: Tuberculosis is an ancient infectious disease that remains one of the major global health problems. Until now, effective, convenient, and affordable methods for diagnosis of PTB were still lacking. Objective: This study focused on constructing a label-free LC-MS/MS-based comparative proteomics between six t Read More

Background: Mechanisms underlying yak adaptation to high-altitude environments have been investigated at the levels of morphology, anatomy, physiology, genome and transcriptome, but have not been explored at the proteome level. Objective: The protein profiles were compared between yak and cattle to explore molecular mechanisms underlying yak adaptation to high altitude conditions. Methods: In the present study, an Read More

Background: The soybean seed’s physiological maturity (R7) period is an extraordinary period for the formation of seed vigor. However, how proteins and their related metabolic pathways in seed and leaf change during seed physiological maturity is still not fully understood. Methods: In the present study, using a pair of pre-harvest seed deterioration-sensitive and -resistant soybean cultivars Ningzhen No. 1 and Xiangdou Read More

Background: The female Aedes aegypti mosquito is a vector of several arthropod-borne viruses, such as Mayaro, Dengue, Chikungunya, Yellow Fever, and Zika. These viruses cause the death of at least 600000 people a year and temporarily disable several million more around the world. Up to date, there are no effective prophylactic measures that would prevent the contact and bite of this arthropod and, therefore, its conse Read More