Current Proteomics - Volume 17, Issue 4, 2020

Background: DNA-binding proteins are very important to many biomolecular functions. The traditional experimental methods are expensive and time-consuming, so, computational methods that can predict whether a protein is a DNA-binding protein or not are very helpful to researchers. Machine learning has been widely used in many research areas. Many researchers have proposed machine learning methods for DNA-bi Read More

Background: Protein-Protein Interactions (PPIs) play a key role in various biological processes. Many methods have been developed to predict protein-protein interactions and protein interaction networks. However, many existing applications are limited, because of relying on a large number of homology proteins and interaction marks. Methods: In this paper, we propose a novel integrated learning approach (RF-Ada- Read More

Background: The ligand-receptor interaction plays an important role in signal transduction required for cellular differentiation, proliferation, and immune response process. The analysis of ligand-receptor interactions is helpful to provide a deeper understanding of cellular proliferation/ differentiation and other cell processes. Methods: The computational technique would be used to promote ligand-receptor interactions r Read More

Background: The DNA-binding proteins is an important process in multiple biomolecular functions. However, the tradition experimental methods for DNA-binding proteins identification are still time consuming and extremely expensive. Objective: In past several years, various computational methods have been developed to detect DNAbinding proteins. However, most of them do not integrate multiple information. Methods: I Read More

During the last three decades or so, many efforts have been made to study the protein cleavage sites by some disease-causing enzyme, such as HIV (Human Immunodeficiency Virus) protease and SARS (Severe Acute Respiratory Syndrome) coronavirus main proteinase. It has become increasingly clear via this mini-review that the motivation driving the aforementioned studies is quite wise, and that the results acquired Read More

Background: Alterations in airway smooth muscle cells cause an increase in their mass and result in a significant impact on airway remodeling diseases such as asthma and chronic obstructive pulmonary disease. Several studies have used platelet-derived growth factors to stimulate the alterations of airway smooth muscle cells. Objective: This review discusses the platelet-derived growth factor-stimulated alterations of ai Read More

Background:S. dysenteriae is the causative agent of shigellosis, a severe form of bacillary dysentery and this infectious disease is still a health problem worldwide, especially in children. The most important proteins of the Shigella type III secretion system are IpaB and IpaD, which attach to the intestinal epithelial cells and provide the possibility of invasion and disease. These two proteins with immunogenic properties can be Read More

Background: The protozoan Giardia duodenalis, which causes giardiasis, is an intestinal parasite that commonly affects humans, mainly pre-school children. Although there are asymptomatic cases, the main clinical features are chronic and acute diarrhea, nausea, abdominal pain, and malabsorption syndrome. Little is currently known about the virulence of the parasite, but some cases of chronic gastrointestinal alterati Read More