Current Proteomics - Volume 17, Issue 5, 2020

Infectious diseases have caused historical pandemics in the world. Three strategies, including sanitation programs, antimicrobial drugs, and vaccines are considered for the prevention and treatment of infectious diseases. Today, some infectious diseases cause millions of mortalities universally. Due to the emergence of antibiotic-resistant pathogens, as well as some limitations of traditional vaccines, focusing on novel Read More

Background: Licorice is an herbal medicine applied extensively worldwide, and most of the licorice for clinical consumption is provided by Glycyrrhiza uralensis Fisch. Evidence suggests that there is a significant difference in the metabolite composition of licorice from different ecotypes. Objective: To better understand the proteomic changes and molecular mechanisms of metabolite formation in wild and cultivated Glycyr Read More

Background: The tolerogenic homeostasis in Breast Cancer (BC) can be surpassed by rationally designed immune-encouraging constructs against tumor-specific antigens through immunoinformatics approach. Objective: Availability of high throughput data providing the underlying concept of diseases and awarded computational simulations, lead to screening the potential medications and strategies in less time and cost. Despi Read More

Background: Post-Translational Modifications (PTMs), such as phosphorylation, are an essential regulatory mechanism of protein function and are associated with a range of biological processes beyond the genome and transcriptome. Spiroplasma eriocheiris, a wall-less helical bacterium, is one of the smallest self-replicating bacteria, and is a novel pathogen of freshwater crustaceans. Methods: Protein phosphorylation in S. erioc Read More

Background: Silver nanoparticles pose high antibacterial properties against multi drugresistant and non-resistant bacteria. However, bacteria acquire resistance against chemically synthesized silver nanoparticles after repeated exposure. Therefore, there is an inevitable need to understand the mechanistic behavior of silver nanoparticles. Objective: In this study, we have performed a complete proteomic analysis Read More

Background: Invasion of HIV in human occurs through DC-SIGN’s interaction via the mucosal lining during sexual transmission. Bovine Lactoferrin (bLF) has been known to hinder this invasion via its interaction with DC-SIGN. Hitherto, protein assays have taken place but molecular-level studies remain unexplored. Methodology: The 3D structures of the three proteins were studied. After protein docking (bLF_DCSIGN and gp120_D Read More

Background: Breast cancer is the most occurring cancer in women with high incidence rates both in developed and developing countries. Among different types of breast cancers, Triple Negative Breast Cancer (TNBC) is the most aggressive type as it lacks receptors of Estrogen, Progesterone and Human Epidermal Growth Factor Receptor 2, common diagnostic biomarkers for the disease. Since early detection of TNBC can sav Read More

Background: Aspergillus terreus is a major etiological agent among fungal pathogens and emerged as an opportunistic pathogen in immunocompromised patients. Objective: To explore mycelial proteins to shed light on chemical and molecular details that contribute to pathogenesis including intrinsic resistant to amphotericin B (AmB), and biomolecules associated with biofilm formation. Methods: The m Read More