Current Proteomics - Volume 14, Issue 2, 2017

Diabetic neuropathy is the most common complication of diabetes mellitus and a major factor associated with foot ulcers and amputations in patients with diabetes. Diagnosing diabetic neuropathy in early stages may reduce the risk for comorbidities. However, it still represents a major challenge for the healthcare providers, despite the complexity of available techniques. Discovering new serum biomarkers, useful for ea Read More

Background: Melanoma is an aggressive malignancy and its increasing incidence worldwide has boosted interest in biomarker discovery in blood to monitor melanoma development, therapy efficacy, and to find new therapy targets. Our study aimed to discover candidate protein biomarkers that could have a double role, differentiate between melanoma patients and controls and distinguish patients with good clinical outcomes fro Read More

Background: Secretory production of heterologous proteins in bacterial hosts has been a topic of interest due to its various advantages. However, it is difficult to achieve because of process complexity and the need for selection of an appropriate signal peptide for each protein and host. IL- 11, marketed as Neumega®, is a multifunctional cytokine approved for platelet recovery in chemotherapy- induced thrombocytopenia. Obj Read More

Background: The chemokine receptors are an important subfamily of rhodopsin-like G protein-coupled receptors (GPCRs) and have fundamental roles in many physiological and pathological processes. Therefore, they are among the drug targets in pharmaceutical development. Objective: The binding of these receptors with their chemokines is complex. The present work aims to contribute to a better understanding of this com Read More

Objective: Osteoporotic fracture is one of the most common health risks and aggravates the quality of life among postmenopausal women worldwide. In this study, osteoporosis-associated protein biomarkers were identified from urine of osteoporotic female Sprague-Dawley rats developed by ovariectomy. Method: Four months after the operation, the bone mineral density of the femur of ovariectomized rats was Read More

Objectives: We have analyzed the influence of Amorphophallus konjac tuber (KONJAC) extracts on protein expression of mitochondrial in cell line SGC-7901, identified those differentially expressed by mass spectrometry, and built a network of differentially expressed proteins using software. This provided the basis for a study of the molecular mechanisms of the anti-gastric cancer effects. Method: The cell viability was evaluat Read More

Objectives: Due to the complexity of DNA-Repair Mechanisms in Plants, this work will give more insights to better understanding the dark DNA-repair mechanism through the interactome analysis of DDBs proteins in plants. Method: Bioinformatics tools had been used in this work to analyses DNA Damage-Binding proteins; MSA, Phylogenetic tree construction, 3-D structure prediction, Domain analysis, subcellular localization p Read More

Background: Estrogen receptor-α positive breast cancer is the most common dreadful disease and leading cause of death among women. In majority of human breast cancer, the interactions between kinases and ERα are considered to be critical in signaling pathway. Many kinases are known to regulate ERα activity. Recently Lemur tyrosine kinase-3 was identified as predictive oncogenic ERα regulator with a vital role in Read More