Current Proteomics - Volume 14, Issue 1, 2017

Soybean is a widely cultivated crop and it serves as a major source of protein and vegetable oil. The growth and yield of soybean are markedly affected by adverse environmental conditions including abiotic and biotic stresses. Nanoparticles (NPs), which are the materials with specific size ranging from 1 to 100 nm, are used in agricultural products on a large scale. NPs cause differential growth effects on plants depending Read More

Peptide drugs have received more attention as potential next-generation drugs or drug leads. Such attention is primarily due to the higher target selectivities and efficiencies of peptide drugs. Moreover, peptide drugs typically have lower accumulation rates and toxicities. Although peptide drugs have advanced significantly in the 21st century, two bottlenecks (disadvantages) primarily hinder peptide drug research and devel Read More

Objective: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and becoming an important public health concern in the world. However, the molecular mechanism of the pathogenesis in NAFLD is still unclear. Method: In this study, in vitro model of NAFLD was established and differential expression of proteins in this cellular model was investigated by using proteomic technique. Result: By using Read More

Background: Aggregation of Human α-synuclein protein into well-ordered amyloid fibrils is critical at the onset of Parkinson’s disease (PD), a progressive and irreversible neurodegenerative disorder. In the recent past, the importance of tyrosine residues in the fibrillation process of α-synuclein has been highlighted but their definite role in the early events of fibrillation is not clear. Objective: To understand the role of Ty Read More

Background: Low temperature is a serious environmental factor that affects plant growth and cultivation. As one of the most popular fruit crop in the world, grapevine exhibited much difference in cold stress tolerance of different cultivars. Objective: To understand the cold tolerance mechanism in grapevine and provide certain proteomics data may contribute to its breeding for enhancement of cold tolerance. Metho Read More

Objectives: Bio-informatics methodologies have made possible to profile the global composition of tissue or organelle at a specific point or under particular developmental or disease state. In schizophrenia, research has extensively focused on identification of the alterations associated with gene and protein expression profiling. An additional target of the present study is the assorted mechanisms by which post-translational Read More

Background: Lung cancer is one of the most common causes of cancer-related mortality, and its incidence is increasing steadily worldwide. NSCLC represents approximately 83% of lung cancer cases, including different subtypes, among clinically histological lung cancer types. Materials and Methods: In this study, we aimed to identify proteome level differences between NSCLC tumor and tumor-adjacent non-tumor tissue sa Read More

Background: The Pekin duck, bred from the mallard (Anas platyrhynchos) in china, is one of the most famous meat duck species in the world. However, it is more sensitive to heat stress than Muscovy duck, which is believed to have originated in South America. Objective: This study aims to uncover the temperature-dependent proteins of two duck species using comparative proteomic approach. Methods: we performed the Read More