Current Proteomics - Volume 10, Issue 3, 2013

Research and practice in neuro-endocrine(NE) markers is focused on the detection and diagnosis of neuroendocrine tumors (NETs), as epithelial neoplasms arise in many organs and are clinically characterised by an intriguingly disperse behaviour, ranging from the almost invariably benign cases of carcinoids to the highly aggressive ones of small cell carcinomas. In addition to specific hormonal peptides, NETs produce (and Read More

This review will focus on the elements of the skin’s immune system, immune cells and/or non-immune cells that support immune mechanisms, molecules with immune origin and/or immune functions that are involved in skin carcinogenesis. All these immune elements are compulsory in the development of skin tumors and/or sustainability of the neoplastic process. In this light, recent data gathered in this review will acknowle Read More

Oral squamous cell carcinoma (OSCC) is the most frequent malignancy of the oral cavity, highly invasive with unfavourable prognosis and unimproved 5-year survival rate for at least two decades. Comprehensive analysis of the proteome in OSCC patients (tissue tumor, blood and saliva) was extensively performed in the last years in order to identify reliable biomarkers for early detection, prognosis or treatment eff Read More

Digestive tract cancers – gastric-, colorectal-, pancreatic-, hepatocarcinoma- and esophageal are some of the most frequent cancers; they are characterized by invasivity, metastatic potential and bad outcomes. This group includes several of the most critical cancers (those ranked 2nd-4th in cancer related mortality), and, despite all efforts, they remain with low survival rates and lack of success of therapies. Discovery of no Read More

Omics are wide concepts used to define metadata in life sciences and are increasing in number with the development of science. Thus the era of omics started with genomics, which studies the genome; followed by proteomics which focuses on proteins and metabolomics which covers the field of metabolites. Cellomics deals with "the study of cells" or "the knowledge of cellular phenotype and function". One of the main are Read More

High grade gliomas represent one of the most aggressive and treatment-resistant types of human cancer, with only 1–2 years median survival rate for patients with grade IV glioma. The treatment of glioblastoma is a considerable therapeutic challenge; combination therapy targeting multiple pathways is becoming a fast growing area of research. This review offers an up-to-date perspective of the literature about current mole Read More

Mycobacterium tuberculosis is the causative agent of tuberculosis, an old formidable scourge of global public health. Despite decades of intensive studies on the biology and physiology of M.tuberculosis, the function of about one-quarter open reading frame (ORF) of the M.tuberculosis genome remains elusive. In order to determine the size of M.tuberculosis proteome during normal in vitro growth, shotgun proteomic profiling a Read More