Current Proteomics - Volume 10, Issue 1, 2013

Membrane protein, which is closely related to cellular biological functions, is a vital component of cell membranes. Predicting membrane protein and its types is a challenging task that offers promising results. This paper proposes a novel membrane detection method that is more efficient and accurate than traditional technologies. Two methods were used to extract features from protein sequences. The 20-D feature was extra Read More

Animals produce a large variety of antimicrobial peptides that play an important role in natural innate immunity and controlling microbial infections. Snakes are classified into the phylum Chordata and class Reptilia, within the animal kingdom. Snake venoms are extensive mixtures that contain a large number of biologically active proteins/ peptides that represent a promising source of potential therapeutics for both humans and a Read More

Hepatocellular carcinoma (HCC) with more than 700,000 deaths every year is the most prevalent type of liver cancer and a global concern. It is the fifth most common cancer worldwide and has a poor general prognosis. Chronic hepatitis B virus (HBV) infection is a major cause of HCC. The HBV-infected individual has 100 times higher risk of developing HCC. The x protein of HBV (HBx) has been shown to involve in the developme Read More

The failure of proteins to fold correctly result in amyloidosis. Therefore, amyloid plaque prediction has become significant to narrow down the exploration of anti- amyloidosis and related drugs. In this research article, we propose a unique hybrid approach to computationally predict the formation of amyloid plaques by exploiting diversity in the feature vector extracted from protein sequences and structures. The diversit Read More

Hyperhomocysteinemia (HHcy): A condition that epidemiological studies have shown to be associated with increased risk of vascular disease and type 2 diabetes (T2D), arises from disrupted homocysteine (Hcy) and glucose metabolism. Our previous studies evaluating the regulation of Hcy metabolism from the molecular, cell, animal and population levels have demonstrated that utilization of Hcy by the trans-sulfuration and Read More

The central nervous system (CNS) encompasses complex groups of cells that coexist to form the functional units of brain mainly comprising three cell types: neurons, oligodendrocytes and astrocytes. The network of these cells through interaction between each other leads to formation of complex organizations such as nodes of ranvier, paranodes, juxtaparanodes etc. Therefore, regions of molecular complexity in brain ha Read More