Skip to content
2000
Volume 10, Issue 3
  • ISSN: 1570-1646
  • E-ISSN: 1875-6247

Abstract

Oral squamous cell carcinoma (OSCC) is the most frequent malignancy of the oral cavity, highly invasive with unfavourable prognosis and unimproved 5-year survival rate for at least two decades. Comprehensive analysis of the proteome in OSCC patients (tissue tumor, blood and saliva) was extensively performed in the last years in order to identify reliable biomarkers for early detection, prognosis or treatment efficacy. We discuss herein the up-dated recent data regarding neoplastic / stromal interactions related biomarkers such as cadherins, catenins, matrix metalloproteinases, snai1, snai2, desmoglein 3, ezrin, zyxin, ILK, EMMPRIN, bone sialoprotein, dentin sialophosphoprotein, osteopontin, fascin, podoplanin, calreticulin. These molecules are involved either in cell-cell adhesion, cell-extracellular matrix interactions or regulation of matrix metalloproteinases that are expressed in OSCC, most of them in correlation with tumor aggressivity. The pattern of the expression of most of these biomolecules in correlation with prognosis and/or histopathologic parameters with previously proven prognostic significance (such as tumor stage or presence of lymph node metastases) recommend them as possible biomarkers; however, considering the multitude of the studies involving several of this markers and the inhomogeneous results, further investigations are required in order to validate them for daily practice use.

Loading

Article metrics loading...

/content/journals/cp/10.2174/1570164611310030004
2013-10-01
2025-06-12
Loading full text...

Full text loading...

/content/journals/cp/10.2174/1570164611310030004
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test