Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Cosmetic Science
  4. Volume 1, Issue 1
  5. Article
Volume 1, Issue 1
  • ISSN: 2666-7797
  • E-ISSN: 2666-7800

Abstract

Kaposi's sarcoma (KS) is a tumor of endothelial derivation, which primarily affects the skin and is mainly related to the type 8 Human Herpesvirus (HHV8). Its onset is favored by immunosuppression, although the most common form is the classic or sporadic KS mainly developing in elderly men of Mediterranean and Eastern European origin. Different therapeutic options are available, depending on the clinical variant, progression pattern, and comorbidities. The treatment of localized forms includes surgical excision, laser treatment, cryosurgery, radiotherapy, imiquimod 5%, and intra-lesion injection of cytotoxic drugs; on the other hand, the treatment of widespread disease encompasses radiotherapy and chemotherapy.

In this scenario, Electrochemotherapy (ECT), has shown to be an effective alternative to traditional treatment for disseminated KS skin lesions. The rationale of ECT relies on the local application of short, high-voltage electric pulses, able to open transient pores in the cell membrane (reversible electroporation that increases the delivery of some poorly permeant cytotoxic agents into the cytosol.

Herein, we performed a retrospective analysis on 9 KS patients treated with ECT at our center between June 2016 and January 2020. The rate of Complete Response (CR) was 77.8% after the first cycle of treatment and 88.9% after the second course, with an overall response (OR) of 100%.

Sustained local control of treated lesions was present in 77.8% of patients 6 months after the treatment and all of them reported only mild local toxicity, together with an excellent functional and cosmetic outcome, in agreement with data obtained from the comparison with the recent literature.

© 2022 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cosci/10.2174/2666779701666210805100043
2022-04-01
2024-11-22

  • From This Site

    /content/journals/cosci/10.2174/2666779701666210805100043
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. RaduO. PantanowitzL. Kaposi sarcoma.Arch. Pathol. Lab. Med.2013137228929410.5858/arpa.2012‑0101‑RS 23368874
     [Google Scholar]
  2. CurtissP. StrazzullaL.C. Friedman-KienA.E. An Update on Kaposi’s Sarcoma: Epidemiology, Pathogenesis and Treatment.Dermatol. Ther. (Heidelb.)20166446547010.1007/s13555‑016‑0152‑3 27804093
     [Google Scholar]
  3. GoncalvesP.H. ZiegelbauerJ. UldrickT.S. YarchoanR. Kaposi sarcoma herpesvirus-associated cancers and related diseases.Curr. Opin. HIV AIDS2017121475610.1097/COH.0000000000000330 27662501
     [Google Scholar]
  4. BishopB.N. LynchD.T. Kaposi Sarcoma.StatPearls.Treasure Island, FLStatPearls Publishing2020
     [Google Scholar]
  5. Régnier-RosencherE. GuillotB. DupinN. Treatments for classic Kaposi sarcoma: a systematic review of the literature.J. Am. Acad. Dermatol.201368231333110.1016/j.jaad.2012.04.018 22695100
     [Google Scholar]
  6. SchneiderJ.W. DittmerD.P. Diagnosis and treatment of kaposi sarcoma.Am. J. Clin. Dermatol.201718452953910.1007/s40257‑017‑0270‑4 28324233
     [Google Scholar]
  7. MartyM. SersaG. GarbayJ.R. GehlJ. CollinsC.G. SnojM. BillardV. GeertsenP.F. LarkinJ.O. MiklavcicD. PavlovicI. Paulin-KosirS.M. CemazarM. MorsliN. SodenD.M. RudolfZ. RobertC. O’SullivanG.C. MirL.M. Electrochemotherapy – An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Pro-cedures of Electrochemotherapy) Study.Eur. J. Cancer, Suppl.200641131310.1016/j.ejcsup.2006.08.002
     [Google Scholar]
  8. BertinoG. SersaG. De TerlizziF. OcchiniA. PlaschkeC.C. GroseljA. LangdonC. GrauJ.J. McCaulJ.A. HeuvelingD. CemazarM. StrojanP. de BreeR. LeemansC.R. WesselI. GehlJ. BenazzoM. European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results of the treatment of skin cancer.Eur. J. Cancer201663415210.1016/j.ejca.2016.05.001 27267144
     [Google Scholar]
  9. CampanaL.G. TestoriA. CuratoloP. QuaglinoP. MocellinS. FramariniM. BorgognoniL. AsciertoP.A. MozzilloN. GuidaM. BucherS. RotunnoR. MarencoF. De SalvoG.L. De PaoliA. RossiC.R. BonadiesA. Treatment efficacy with electrochemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumors.Eur. J. Surg. Oncol.201642121914192310.1016/j.ejso.2016.06.399 27424789
     [Google Scholar]
  10. CuratoloP. QuaglinoP. MarencoF. ManciniM. NardòT. MorteraC. RotunnoR. CalvieriS. BernengoM.G. Electrochemothera-py in the treatment of Kaposi sarcoma cutaneous lesions: A two-center prospective phase II trial.Ann. Surg. Oncol.201219119219810.1245/s10434‑011‑1860‑7 21822561
     [Google Scholar]
  11. BonadiesA. BertozziE. CristianiR. GovoniF.A. MiglianoE. Electrochemotherapy in skin malignancies of head and neck cancer pa-tients: Clinical efficacy and aesthetic benefits.Acta Derm. Venereol.201999131246125210.2340/00015555‑3341 31612236
     [Google Scholar]
  12. QuaglinoP. MatthiessenL.W. CuratoloP. MuirT. BertinoG. KunteC. OdiliJ. RotunnoR. HumphreysA.C. LetuléV. Maren-coF. CuthbertC. AlbretR. BenazzoM. De TerlizziF. GehlJ. Predicting patients at risk for pain associated with electrochemothera-py.Acta Oncol.201554329830610.3109/0284186X.2014.992546 25591818
     [Google Scholar]
  13. FanJ.W. WanX.F. YiB. DongJ.C. AbulizeP. Clinicopathological analysis of 114 cases of typical Kaposi’s sarcoma in Xinjiang Uy-gur autonomous region, China.Mol. Med. Rep.20171645495549810.3892/mmr.2017.7283 28849228
     [Google Scholar]
  14. StaritaN. Di MontaG. CerasuoloA. MaroneU. AnnicielloA.M. BottiG. BuonaguroL. BuonaguroF.M. TorneselloM.L. Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma.Infect. Agent. Cancer2017123510.1186/s13027‑017‑0147‑4 28649271
     [Google Scholar]
  15. Di MontaG. CaracòC. BenedettoL. La PadulaS. MaroneU. TorneselloM.L. BuonaguroF.M. SimeoneE. AsciertoP.A. Moz-zilloN. Electrochemotherapy as “new standard of care” treatment for cutaneous Kaposi’s sarcoma.Eur. J. Surg. Oncol.2014401616610.1016/j.ejso.2013.09.002 24075826
     [Google Scholar]
  16. LatiniA. BonadiesA. TrentoE. BultriniS. CotaC. SolivettiF.M. FerraroC. ArdigòM. AmorosiB. PalamaraG. BucherS. GiulianiM. Cordiali-FeiP. EnsoliF. Di CarloA. Effective treatment of Kaposi’s sarcoma by electrochemotherapy and intravenous bleomycin administration.Dermatol. Ther. (Heidelb.)201225221421810.1111/j.1529‑8019.2012.01437.x 22741941
     [Google Scholar]
  17. SkarlatosI. KyrgiasG. MosaE. ProvatopoulouX. SpyrouM. TheodorouK. LepourasA. GounarisA. KoukourakisM. Elec-trochemotherapy in cancer patients: First clinical trial in Greece.In Vivo201125226527421471545
     [Google Scholar]
  18. RotunnoR. CampanaL.G. QuaglinoP. de TerlizziF. KunteC. OdiliJ. GehlJ. RiberoS. LiewS.H. MarconatoR. BrizioM. CuratoloP. Electrochemotherapy of unresectable cutaneous tumours with reduced dosages of intravenous bleomycin: Analysis of 57 pa-tients from the International Network for Sharing Practices of Electrochemotherapy registry.J. Eur. Acad. Dermatol. Venereol.20183271147115410.1111/jdv.14708 29178483
     [Google Scholar]
  19. FalkH. MatthiessenL.W. WoolerG. GehlJ. Calcium electroporation for treatment of cutaneous metastases; A randomized double-blinded phase II study, comparing the effect of calcium electroporation with electrochemotherapy.Acta Oncol.201857331131910.1080/0284186X.2017.1355109 28816072
     [Google Scholar]
  20. GroseljA. BosnjakM. StrojanP. KrzanM. CemazarM. SersaG. Efficiency of electrochemotherapy with reduced bleomycin dose in the treatment of nonmelanoma head and neck skin cancer: Preliminary results.Head Neck201840112012510.1002/hed.24991 29130624
     [Google Scholar]
/content/journals/cosci/10.2174/2666779701666210805100043
Loading
Electrochemotherapy in the Treatment of Kaposi’s Sarcoma: A Single Centre Cohort Study and a Comparison with the Literature Data
Curr. Cosm. Sci. 1, e050821195286 (2022); https://doi.org/10.2174/2666779701666210805100043
/content/journals/cosci/10.2174/2666779701666210805100043
/content/journals/cosci/10.2174/2666779701666210805100043
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): bleomycin; cosmetic outcomes; effectiveness; Electrochemotherapy; kaposi’s sarcoma; treatment

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test