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2000
Volume 3, Issue 1
  • ISSN: 2666-7797
  • E-ISSN: 2666-7800

Abstract

Melasma, a prevalent hyperpigmentation skin disorder, poses significant challenges in dermatology clinics. Despite its global impact, conventional treatment options often entail potential side effects and limitations, necessitating the search for alternative therapeutic strategies.

This narrative review aims to advance the understanding of melasma from the perspective of Unani medicine, an ancient healing system recognized by the World Health Organization. It seeks to explore potential therapeutic avenues within the Unani medical paradigm by synergizing ancient wisdom with contemporary perspectives.

The review delves into the Unani scholars' understanding of melasma, known as , drawing from the wisdom of renowned scholars. Their insights into the multifactorial etiology of melasma, including pathogenesis, treatment approach, and recommended prescriptions, are discussed.

The descriptions of melasma by Unani scholars have documented the etiopathogenesis, risk factors, and management in detail and emphasize personalized interventions based on the pathological concepts of Unani medicine. Moreover, some of these interventions were also investigated in recent clinical trials and found to have comparable efficacy with standard treatment options.

This review fosters the understanding of the pathogenesis of melasma according to Unani concepts and a holistic approach to the management of melasma, drawing from the timeless legacy of the Unani system of medicine. This review may serve as a reference point for future research, enabling the planning of subsequent studies on this disease with a comprehensive understanding of the previous investigations conducted in this field.

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2024-02-02
2025-01-18
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References

  1. Cosmetic DermatologyCosmetic Dermatology For Skin Of Color.McGraw Hill Education2009
    [Google Scholar]
  2. WolffK. Fitzpatricks Color AtlasJ.R. Fitzpatricks Color Atlas and Synopsis of Clinical Dermatology.McGraw Hill Education2009344346
    [Google Scholar]
  3. GawkrodgerD. Ardern-JonesM.R. Dermatology An Illustrated Colour Text.6th edNew YorkElsevier2017
    [Google Scholar]
  4. RaihanA. KumaranM.S. Study of contact sensitivity to cosmetic allergens in melasma.Pigment Int.201963436
    [Google Scholar]
  5. RashmiS. Melasma A MonographJaypee brothersNew Delhi2015
    [Google Scholar]
  6. Jackson-RichardsD. PandyaA.G. Eds.;Dermatology for Skin of Color.New YorkSpringer20142731
    [Google Scholar]
  7. PasseronT. OrtonneJ. Atlas of Pigmentary Disorders.Adis Cham201610.1007/978‑3‑319‑10897‑1
    [Google Scholar]
  8. BusamK.J. Dermatopathology.USAElsevier Saunders2016270
    [Google Scholar]
  9. GoldmanL. AusielloD.A. Cecil Textbook of MedicineELsevier2004
    [Google Scholar]
  10. ShahS.N. API Text Book of Medicine.MumbaiThe Association of Physicians of India2012
    [Google Scholar]
  11. MajoosiA.H.A.I.A. (Urdu translation by Kantoori GH). Kamilus Sana; Vol-2.New DelhiIdara Kitabul Shifa2010
    [Google Scholar]
  12. JainS. Dermatology Illustrated Study Guide and Comprehensive Board Review.New YorkSpringer2012137
    [Google Scholar]
  13. BaumannL. SaghariS. Cosmetic Dermatology Principles and Practice.McGraw Hill Education2009
    [Google Scholar]
  14. S, B. Oxford Handbook of Medical Dermatology.UKOxford University Press2016583
    [Google Scholar]
  15. FreedbergI.M. EisenA.Z. WolffK. AustenK.F. GoldsmithL.A. Fitzpatricks DermatologyK.S.T. General Medicine.USAMcGraw Hill Education2003977978
    [Google Scholar]
  16. GrimesP.E. Management of hyperpigmentation in darker racial ethnic groups.Semin. Cutan. Med. Surg.2009282778510.1016/j.sder.2009.04.00119608057
    [Google Scholar]
  17. SuryakantB. SamipaA. MukherjeeS. PralhadraoB. Dermoscopy - histopathology correlation.Dermoscopy - Histopathology Correlation. AnkadB.S. NikamB.P. MukherjeeS.S. SingaporeSpringer Nature2021163183
    [Google Scholar]
  18. WetterD.A. Dermatology for Skin of Color. In: Mayo Clinic Proceedings2014
    [Google Scholar]
  19. NicolaidouE. AntoniouC. KatsambasA.D. Origin, clinical presentation, and diagnosis of facial hypermelanoses. Dermatol. Clin.2007253321-326, viii.10.1016/j.det.2007.05.00217662897
    [Google Scholar]
  20. KangH.Y. OrtonneJ.P. What should be considered in treatment of melasma.Ann. Dermatol.201022437337810.5021/ad.2010.22.4.37321165205
    [Google Scholar]
  21. Torres-ÁlvarezB. Mesa-GarzaI.G. Castanedo-CázaresJ.P. Fuentes-AhumadaC. Oros-OvalleC. Navarrete-SolisJ. MoncadaB. Histochemical and immunohistochemical study in melasma: Evidence of damage in the basal membrane.Am. J. Dermatopathol.201133329129510.1097/DAD.0b013e3181ef2d4521317614
    [Google Scholar]
  22. MiotL.D. MiotH.A. PolettiniJ. SilvaM.G. MarquesM.E. Morphologic changes and the expression of alpha-melanocyte stimulating hormone and melanocortin-1 receptor in melasma lesions: A comparative study.Am. J. Dermatopathol.201032767668210.1097/DAD.0b013e3181cd439620534990
    [Google Scholar]
  23. BandyopadhyayD. Topical treatment of melasma.Indian J. Dermatol.200954430330910.4103/0019‑5154.5760220101327
    [Google Scholar]
  24. FarshiS. Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma.J. Cosmet. Dermatol.201110428228710.1111/j.1473‑2165.2011.00580.x22151936
    [Google Scholar]
  25. KaliternaD. Melasma review of current treatment modalities and efficacy assessment of a new resorcinol-based topical formulation.Glob. Dermatol.20172017416
    [Google Scholar]
  26. McKeseyJ. Tovar-GarzaA. PandyaA.G. Melasma treatment: An evidence-based review.Am. J. Clin. Dermatol.202021217322510.1007/s40257‑019‑00488‑w31802394
    [Google Scholar]
  27. PrignanoF. OrtonneJ.P. BuggianiG. LottiT. Therapeutical approaches in melasma.Dermatol. Clin.2007253337342[viii].10.1016/j.det.2007.04.00617662899
    [Google Scholar]
  28. GuptaA.K. GoverM.D. NouriK. TaylorS. The treatment of melasma: A review of clinical trials.J. Am. Acad. Dermatol.20065561048106510.1016/j.jaad.2006.02.00917097400
    [Google Scholar]
  29. KhatoonF. HusainN. JabeenA. UddinQ. AzaharM. QureshiA. KhanA.A. Psoriasis with special reference to Unani medicine - A review.Open Health20223112414010.1515/openhe‑2022‑0024
    [Google Scholar]
  30. KhatoonF. AzaharM. JabeenA. UddinQ. HusainN. NaikodiM.A.R. Treatment of chronic plaque psoriasis with herbal Unani formulations: A randomized control trial of efficacy and safety.J. Ethnopharmacol.202229611545610.1016/j.jep.2022.11545635724745
    [Google Scholar]
  31. DoniM. PatelM.I. KhalidM. HusainN. KhanM.Q. AyeshaB. Therapeutic evaluation of herbal formulation in acne vulgaris and its influence on quality of life-A single-arm clinical trial.J. Herb. Med.20223410057710.1016/j.hermed.2022.100577
    [Google Scholar]
  32. WHO Global Centre for Traditional Medicine. Available from: https://www.who.int/initiatives/who-global-centre-for-traditional-medicine (Accessed Aug 6, 2023).
  33. CCRUM.Unani System of Medicine: The Science of Health and Healing; department of ayUSH ministry of Health & family Welfare2013
    [Google Scholar]
  34. AhmadW. SofiG. AlamM.A. ZulkifleM. AhmadB. Understanding Holism in the light of principle underlying practice of Unani Medicine.Rev. Environ. Health202237218919910.1515/reveh‑2021‑000933984879
    [Google Scholar]
  35. Schmidt-StiedenrothK. Unani Medicine in the Making.Amsterdam University Press2020
    [Google Scholar]
  36. HusainN. KhalidM. Aesthetic significance of solah shringar (sixteen ornaments) in unani medicine.J. Complement. Altern. Med. Res.20216981
    [Google Scholar]
  37. KapurM. Basic principles of unani system.Psychological Perspectives on Childcare in Indian Indigenous Health Systems.New DelhiSpringer India2016899510.1007/978‑81‑322‑2428‑0_7
    [Google Scholar]
  38. ImranS. KhalidM. HusainN. KhanM.Q. ShaikhS. The efficacy of topical marham-e-akbar in chronic atopic dermatitis - an open-label interventional study.Drug Metab. Pers. Ther.2022
    [Google Scholar]
  39. HusainN. UddinQ. KazmiM.H. KhalidM. A non-inferiority randomized controlled clinical trial comparing Unani formulations and PUVAsol in non-segmental vitiligo.J. Complement. Integr. Med.202320125025710.1515/jcim‑2021‑005734162019
    [Google Scholar]
  40. JagannathanM. SadagopanK. EkkarakudyJ. AnandanH. Clinico-epidemiological study of patients with melasma in a tertiary care hospital - A prospective study.Int. J. Sci. Stud.20174117120
    [Google Scholar]
  41. TabriR. Firdausul Hikmat.New DelhiIdara Kitabul Shifa2010
    [Google Scholar]
  42. AhmadH.H.J. Tazkira Tu Jaleel; CCRUM.Ministry of Health and Family Welfare2008
    [Google Scholar]
  43. TabriA.M. Moalajat-e Buqratiya; CCRUM.Ministry of Health and Family Welfare1995
    [Google Scholar]
  44. RaziA.M.B.Z. Al Hawi Fil Tib.Saba Publishers1994
    [Google Scholar]
  45. QuamriA.M.H. Ghina Muna Ma Tarjuma Minhajul Ilajssf CCRUM: New Delhi,Ministry of Health and Family Welfare2008
    [Google Scholar]
  46. MajoosiA. Kamilus Sana.CCRUM2010
    [Google Scholar]
  47. ShirbeigiL. RanjbarM. Vascular Etiology of Melasma” the idea which was first presented by avicenna and rhazes.Tradit. Integr. Med.2016166167
    [Google Scholar]
  48. SinaI. Al Qanoon Fil Tib.New DelhiIdara Kitabul Shifa2010
    [Google Scholar]
  49. ZoharI. Kitabul Taisir Fil Mudawat Wat Tadbir.Ministry of Health and Family Welfare1986
    [Google Scholar]
  50. BaghdadiI.H. Kitabul Makhtarat Fil Tib; CCRUM.Ministry of Health and Family Welfare2007
    [Google Scholar]
  51. JurjaniI. Zakheera Khawarzam Shahi.Idara Kitabul Shifa2010
    [Google Scholar]
  52. RizwanH.K.A. Tarjuma Sharah AsbabCCRUM, Ministry of Health and Family Welfare, Govt of India2010
    [Google Scholar]
  53. ArzaniA. Tibbe Akbar
    [Google Scholar]
  54. KhanM.A. Akseere Azam.New DelhiIdara Kitabush Shifa2011
    [Google Scholar]
  55. KhanH. Ajmal. Haziq.KarachiMadina Publication1983
    [Google Scholar]
  56. kabiruddin, M.Bayaz e KabirIdara Kitabul ShifaNew Delhi2010
    [Google Scholar]
  57. HandelA.C. MiotL.D.B. MiotH.A. Melasma: A clinical and epidemiological review.An. Bras. Dermatol.201489577178210.1590/abd1806‑4841.2014306325184917
    [Google Scholar]
  58. AlexisA.F. Skin of Color.A practical guide to dermatologic diagnosis and treatment.Springer2013
    [Google Scholar]
  59. TrivediM.K. YangF.C. ChoB.K. A review of laser and light therapy in melasma.Int. J. Womens Dermatol.201731112010.1016/j.ijwd.2017.01.00428492049
    [Google Scholar]
  60. KhannaN. Illustrated synopsis of dermatology & sexually transmitted diseases.Elsevier2011
    [Google Scholar]
  61. Mette HenriksenR. Objective Determination of Fitzpatrick Skin Type.Dan. Med. Bull.2010578B4153
    [Google Scholar]
  62. OrtonneJ.P. ArellanoI. BerneburgM. CestariT. ChanH. GrimesP. HexselD. Im, S.; Lim, J.; Lui, H.; Pandya, A.; Picardo, M.; Rendon, M.; Taylor, S.; Van Der Veen, J.P.W.; Westerhof, W. A global survey of the role of ultraviolet radiation and hormonal influences in the development of melasma.J. Eur. Acad. Dermatol. Venereol.200923111254126210.1111/j.1468‑3083.2009.03295.x19486232
    [Google Scholar]
  63. NayakC.S. NouveauS. AgrawalD. KohliM. BernerdF. MisraN. Skin hyperpigmentation in Indian population: Insights and best practice.Indian J. Dermatol.201661548749510.4103/0019‑5154.19010327688436
    [Google Scholar]
  64. BhuraM. SharmaS. A clinico-epidemiological study on melasma: A prospective observation.Int. J. Health Clin. Res.2021436163
    [Google Scholar]
  65. Standard Unani Medical Terminology.Central Council For Research in Unani MedicineNew Delhi2012
    [Google Scholar]
  66. ChandpuriK. Mojizul Quanoon.New DelhiQaumi Council Bara-e Faroog-e Urdu Zaban1998
    [Google Scholar]
  67. MojtabaeeM. MokaberinejadR. AdhamiS. MansouriP. RahbarM. Nutritional advice for patients with melasma in iranian traditional medicine.J. Ski. Stem Cell.20163
    [Google Scholar]
  68. VermaK. KumreK. SharmaH. SinghU. A study of various etiological factors in the causation of melasma. Indian J.Clin. Exp. Dermatol.201512832
    [Google Scholar]
  69. AhmadSMR Review on melasma with special reference to treatment in unani medicine.Int. Pharm. Sci20134254
    [Google Scholar]
  70. AquilZ. KhalidM. UddinQ. Potential role of unani medicinal plants in management of kalaf (Chloasma): A review.J. Skin20193113
    [Google Scholar]
  71. JamilS.S. SiddiquiS.A. FazilM. Standard Unani Treatment Guidelines for Common Diseases; Central Council for Research in Unani Medicine.CCRUM2014
    [Google Scholar]
  72. Razi ZakaryyaKitabul Hawi; VOL 21 par.New DelhiCCRUM2007
    [Google Scholar]
  73. TabriA.M. Moalajat Buqratiya.CCRUM1995
    [Google Scholar]
  74. MushtaqS. SultanaA. NikhatS. RehmanM. Concept of systemic cleansing through concoctives and purgatives (Munzij Mushil Therapy) as a regimen in chronic diseases.J. Med. Erud.201422835
    [Google Scholar]
  75. Razi ZakaryyaKitabul Fakhir Fit Tib; Vol-1.New DelhiCCRUM2008
    [Google Scholar]
  76. AntakiD. Tazkirah Oolil Albab; CCRUM.Ministry of Health and Family Welfare2010
    [Google Scholar]
  77. KhatoonF. AzaharM. UddinQ. HusainN. MoinM.S. KhanS. A comprehensive review on Trigonella foenum-graecum L. with special reference to Unani medicine.Comb. Chem. High Throughput Screen.202337143276
    [Google Scholar]
  78. ShamsiY. Clinical evaluation of a topical unani pharmacopoeial formulation tila-e-kalf in the management of melasma (Kalf): A randomized controlled clinical trial.Orig. Res. Artic. AJP202213255264
    [Google Scholar]
  79. QaiyyumI.A. NawabM. KazmiM.H. A randomized controlled clinical trial to evaluate safety and efficacy of a Unani formulation in the management of Kalaf (Melasma).J. Complement. Integr. Med.202320123324010.1515/jcim‑2021‑035334582636
    [Google Scholar]
  80. MahjourM. BanihashemiM. RakhshandehH. VakiliV. KhoushabiA. KakhkiM.T. A triple-blind, randomized trial of a traditional compound as compared to 4% hydroquinone in melasma.J. Herb. Med.20201910030810.1016/j.hermed.2019.100308
    [Google Scholar]
  81. SultanaA. SiddiqueeR.A. KhannaN. AhmadT. ShiffaM. Comparative clinical evaluation of unani formulations in the treatment of melasma.Am. J. PharmTech Res20122
    [Google Scholar]
  82. GauriM. AhmedT. KhanM.S. AliS.J. Therapeutic evaluation of unani herbal medicine for topical application (zimad of tukhme turb, tukhme karafs and sirka) in melasma (Kalaf) - A single blind randomized controlled study.Int. J. Sci. Res.201543841
    [Google Scholar]
  83. Abdul-LatifZ. Randomized clinical trial of unani formulations in chloasma/melasma.Hippocrat. J. Unani Med.201271931
    [Google Scholar]
  84. ZarnigarR. Evaluation of shooneez (Nigella Sativa) and sirka (Sugarcane Vinegar) in kalaf (Melasma).Hippocrat. J. Unani Med.20116145149
    [Google Scholar]
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