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Volume 3, Issue 1
  • ISSN: 2666-7797
  • E-ISSN: 2666-7800

Abstract

Background

Skin aging is a result of the aging process and also intrinsic and extrinsic factors. In order to better understand this process and evaluate anti-aging products, it is necessary to develop models that can recapitulate the biological process of aged skin. Therefore, the aim of this study was to develop an aged skin equivalent model to evaluate these properties.

Methods

Human fibroblasts were incorporated into the collagen matrix and keratinocytes were added and cultured in an air-liquid interface for 21 days. During this period, the matrices were exposed to UV or EX527 to trigger biological aging processes.

Results

The two protocols evaluated demonstrated reduced expression of genes related to longevity and regulation of cellular redox homeostasis, and it was confirmed with histological analysis. Also, the model demonstrated the anti-aging potential of resveratrol.

Conclusion

The model developed is a promising platform for reproducing aged skin and evaluating rejuvenating agents.

© 2024 Bentham Science Publishers
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2023-12-04
2025-01-18

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/content/journals/cosci/10.2174/0126667797269907231118130449
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Development of Aged Skin Equivalent Model
Curr. Cosm. Sci. 3, E041223224169 (2024); https://doi.org/10.2174/0126667797269907231118130449
/content/journals/cosci/10.2174/0126667797269907231118130449
/content/journals/cosci/10.2174/0126667797269907231118130449
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  • Article Type:     Research Article
Keyword(s): aged skin equivalent model; Human fibroblasts; intrinsic and extrinsic factors; resveratrol; skin aging; Skin equivalent

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