Current Organic Synthesis - Volume 8, Issue 5, 2011

Over the past decade, 2-isoxazolines (Δ2-isoxazolines, 4,5-dihydroisoxazoles) have seen a vast increase in their use, both as intermediates in the synthesis of natural and unnatural products, and as bioisosteric functionalities in medicinal compounds. As a result, a number of new methods and expansions in traditional techniques have emerged for the preparation and derivatization of 2-isoxazolines. Considering the burgeoning Read More

Synthesis of novel heterocyclic compounds continues to be an important and challenging task. Isoxazolines are one such class of heterocyclic molecules of significance, since they are frequently found in many compounds that show significant biological activity. They are also of importance since they can be easily transformed into important functional groups. Nitrile oxide cycloaddition with carbon dipolarophiles represents Read More

The utility of 2-isoxazolines (Δ2-isoxazolines, 4,5-dihydroisoxazoles) in the preparation of natural products and other compounds of medicinal and materials interest is growing because the 2-isoxazoline serves both as a desirable functional group and a versatile synthetic intermediate. Nitrile oxide cycloaddition (NOC) to alkenes is the most common method for the preparation of 2- isoxazolines, and the intramolecular version Read More

Methods for the synthesis of 2-isoxazolines and 2-isoxazoline N-oxides that do not involve the [3+2] cycloaddition of a nitrile oxide are reviewed.

This review details the numerous methods of cleavage of 2-isoxazolines and the application of these methods in the synthesis of natural products. 2-Isoxazolines can be cleaved to provide a vast array of functionalities depending on the cleavage conditions used and nature of the substrate. Several cleavage reactions of 2-isoxazolines are covered, including, reductive cleavage by hydrogenolysis using various metal catalysts Read More

The review deals with the chemistry of bimetallic systems containing boron and one of group 14 metalloids or metals attached to the aromatic nucleus. Synthetic approaches to these compounds are described. This is followed by an overview on various applications of these compounds in organic synthesis, supramolecular and material chemistry.

In this review, the recent progress in the use of room temperature ionic liquids (RTILs) as reaction media and/or catalysts for the synthesis of various biologically privileged compounds, mainly heterocycles and nucleoside derivatives, is described.

Pyrimidine derivatives have played an important role in the chemistry of biological systems. This review focuses on recent work of our studies on the synthesis and biological activity of fused pyrimidine derivatives including pyrido[4,3-d]pyrimidine-4(3H)- ones; 3,4-dihydro-pyrido[4,3-d]pyrimidine-8-carbonitriles; pyrazolo[3,4-b]pyrido[4,3-d]-pyrimidine-4-ones; thieno[3',2'-5,6]pyrido [4,3- d]pyrimidin-4(3H)-ones; 1,2,3-tr Read More

The present state of art on the application of carbene-rhodium complexes as stable catalysts for hydroformylation reaction is described. A critical analysis of the influence of pressure and temperature on the hydroformylation of non-modified rhodium complexes and those ones described in the presence of carbenes is also done. Finally, a set of experiments using NHCs prepared by us at different reactions conditions is prese Read More