Current Organic Synthesis - Volume 8, Issue 1, 2011

C-Heteroatom couplings have become increasingly trendy in the past few years and are currently present in many organic synthetic protocols for the preparation of a plethora of chemical products and intermediates with a wide range of applications in different areas including fragrances, pharmaceuticals, agrochemicals and dyes. A remarkable degree of development in importance of such processes in Organic Synthesis Read More

Non-catalytic and catalytic addition reactions were compared in this review, with a special attention paid to the factors controlling selectivity and yields. The scope and limitations of Ni, Pd, Pt, Rh and Au catalysts for the formation of C-S, C-Se and C-Te bonds were discussed with an impact of development of Green chemical methods.

Transition-metal-catalyzed coupling of amines with aryl halides (or pseudo-halides) has evolved as the most versatile method available to forge carbon-nitrogen bonds. However, due to economic and environmental concerns, the quest for more attractive protocols in both academic and industrial domains has been pursued. In this review, we have summarized recent developments in the use of alternative methodologies, Read More

Organocopper chemistry has long been known to be powerful synthetic methodology leading to the generation of C-C, C-O, C-N, C-S and C-X bonds. Advances in catalytic and stoichiometric organometallic reactions for the formation of C-C bonds from unfunctionalised arenes, e.g. by activation-functionalisation of a C-H bond, provides diverse and applicable reaction conditions for direct functionalisation. This review covers the b Read More

A review dealing with iminosugars as inhibitors of α-L-fucosidases is presented. The different synthetic approaches for the preparation of the most relevant ones as well as their inhibitory properties are presented.

Dehydroaltenusin has been isolated from Alternaria tenuis and other fungal species. It exhibits various biological activities such as growth inhibition of wood-damaging fungi, inhibition of calmodulin-dependent myosin light chain kinase, anti-HIV activity, and inhibition of mammalian DNA polymerase α (pol α). These significant biological activities, as well as the unique structural properties of dehydroaltenusin, have stimula Read More