Current Organic Synthesis - Volume 8, Issue 3, 2011

Recently, development of environmentally friendly reactions has been of central importance in modern synthetic organic chemistry. Water is among the most environmentally friendly and least expensive solvents, and therefore reactions mediated by water should constitute the ideal green chemistry. However, since many organic compounds have limited solubility in water, efficient water-mediated reactions with high Read More

Water has proved to be an excellent reaction medium for the definition of highly chemically-efficient and environmentallyfriendly synthetic processes. In several cases, by exploiting the unique properties of water it has been possible to realize more selective and efficient processes than those performed in organic media, including the ring-opening of epoxides by nucleophiles. In this review article the role of water in influ Read More

This review surveys a range of reactions in aqueous media mainly performed from the authors team, some of the results being only disclosed in PhD thesis. Hydrophilic ligands, [(HOCH2CH2NHCOCH2)2NCH2]2 or L-proline, have been used to carry out Cucatalyzed allylic benzoyloxylations and Pd-catalyzed allylic alkylations, isomerizations, telomerizations or cascade reactions. The determinant role of water has been exemplifie Read More

The progress of development in chiral Lewis acid catalyzed reaction in water is described. Lewis acid surfactant-combined catalyst and chiral bipyridine ligand complex realized catalytic asymmetric hydroxymethylation and ring-opening reaction in water successfully. Furthermore, silica-supported Lewis acid catalyst was applied for asymmetric hydroxylation in water.

The synthesis of highly functionalized molecules using multicomponent reactions became increasingly important in organic and medicinal chemistry. The Biginelli reaction is a typically one-pot three-component cyclocondensation between an aldehyde, a β- ketoester and urea leading to multifunctionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs), which provide various possibilities for transformation of the dihydropyrimi Read More

In the past ten years, the development of efficient methods for the synthesis of A-ring 1,7-enyne synthons is one of the most fascinating aspects in the area of active vitamin D3 research. Many concise and practical approaches to construct A-ring 1,7-enyne fragments have been developed, leading to the synthesis of numerous biologically interesting vitamin D3 derivatives, differing in both stereochemistry and substituents in Read More

The tetrapyrrolic uroporphyrinogen III is the common precursor of heme, chlorophylls, bacteriochlorophylls, vitamin B12 and related porphyrinoids. Heme is a prosthetic group of many proteins such as myoglobin and hemoglobin, and enzymes such as cytochrome P450 and peroxidase. Chlorophylls and bacteriochlorophylls are the basic components involved in electron and energy transfer in photosynthesis. Cobalamine Read More

Ionic liquids have been emerging as a versatile class of green solvents with many projected advantages compared with conventional media. They have been described as “designer solvents” whose properties such as solubility, density, refractive index, and viscosity can be adjusted to suit requirements simply by making changes to the structure of either anion or cation or both. In organic synthesis, ionic liquids have been e Read More