Current Organic Synthesis - Volume 8, Issue 2, 2011

The application of the principals of Green Chemistry are becoming more and more common in organic synthesis, and the design of sustainable synthetic methods is more important today than ever. The volume of the industrial production of chemicals, pharmaceuticals, agrochemicals, or consumer goods directly related to the chemical industry (e.g. plastics, dyes etc.), makes the traditional ways obsolete and impossible to Read More

One of the major challenges confronted by modern chemists is the development of sustainable chemistry to maintain environmental chastity. With this perspective in mind, heterogeneous organometallic chemistry has been intensively investigated in recent times. The advantages offered by the heterogeneous catalysts are ease of separation of product, reusability of the catalyst, improved efficiency, eco-compatibility and econo Read More

This review discusses the results of the application of efficient and recyclable palladium catalysts providing highly selective product formation in the Heck reaction. Such green approach promises to result in new catalysts with properties similar to those of homogeneous palladium complexes and environmentally benign protocols. The review focuses on new, exciting results disclosed during the last 5 years.

Recent advances in the development of heterogeneous catalytic hydrogenation reactions are reviewed. The work includes two chapters, highlighting the major types of commercially available solid hydrogenation catalysts and the discussion of recent results related to the hydrogenation of major functional group types. Efforts have also been made to summarize contemporary results in microwave- and ultr Read More

This paper reviews recent advances in polymer-supported acid catalysts and their applications in organic synthesis. The discussion is mainly divided into the polymer-supported Bronsted acids and Lewis acids and subdivided by the nature of the reactions. In the former section, organic reactions catalyzed by polymer Bronsted acids, such as polymers functionalized with sulfonic acid (e.g., Friedel- Craft reactions, etherification, est Read More

Recent advances in the development of environmentally benign heterogeneous catalytic microwave-assisted synthetic reactions are reviewed. The work includes two main chapters, highlighting acid and metal-catalyzed reactions. The literature data are summarized based on the chemical nature of reaction types, such as condensations, protection-deprotection, rearrangements, cyclizations, couplings etc.

Peptides have numerous application possibilities in chemistry, biology, medicine, and pharmaceutical and materials sciences. Their traditional synthesis, however, usually poses major environmental problems. The goal of this review is to evaluate classic and contemporary methods and highlight efforts toward environmentally benign synthesis of peptides.

The biomimetic transamination of fluorinated carbonyl compounds, represent the most methodologically concise and generalized approach to the family of fluorine-containing amines and amino acids. Such amino compounds are of critical importance in the medicinal, bioorganic, biochemistry research and pharmaceutical industry. This review summarizes all of the synthetically and methodologically important achievements in t Read More

The development of combinatorial chemistry has significantly improved the efficiency of compound library synthesis for highthroughput screening. This technology could also be used to address the green chemistry concerns in organic synthesis. The combination of microwave reactions, multicomponent reactions, and fluorous separations to synthesize organic compounds described in this paper have demonstrated the a Read More

This Review article presents all available in the literature data on optical purification of enantiomerically enriched organic compounds via simple procedure of sublimation. The material is arranged in a chronological order from early publications to current research. Relatively small amount of the results reported in the literature suggest that this area of research is still in its infancy it terms of commonly accepted experimental Read More