Current Organic Synthesis - Volume 7, Issue 6, 2010

C-C bond forming reactions are currently present in many organic synthetic protocols for the preparation of a plethora of chemical products and intermediates with a wide range of applications in different areas including fragrances, pharmaceuticals, agrochemicals and dyes. The fascinating journey from serendipity to discovery of C-C coupling reactions started in the early 1970s with the first reports of the Suzuki, Heck, Sono Read More

To mitigate the growing production of CO2 (a powerful Green House Gas), the scientific community is taking a step beyond CO2 capture/storage and trying to utilize CO2 for the production of chemicals and fuels. Although a number of organic syntheses using carbon dioxide are known, only a few were applied in industry. The direct carboxylation of organic compounds for the formation of the moieties C-COOH and C-COOR is s Read More

Carbon-carbon coupling reactions via transition-metal-catalyzed processes have been intensively developed for their important synthetic applications. However, due to both economical and environmental concern, development of novel polymer supported catalysts is of great deal of attention in recent years. The use of these catalysts offers several advantages such as easy workup of the products and recovery of the Read More

C-C and C-Heteroatom couplings are among the most relevant processes in Organic Synthesis. These reactions can provide access to a wide range of carbon-carbon and carbon-heteroatom scaffolds that find applications in many different areas including agriculture, pharmacy, medicine, cosmetics and natural products. Current society's driving force towards more efficient methodologies (with improved environmental co Read More

Biomass represents the type of renewable energy source that will play a substantial role in the future global energy balance, as it is the only renewable source with the potential to be converted to liquid, solid and gaseous fuels. Today lignocellulosic biomass appears to be the cheapest and most abundant biomass feedstock, yet no economically and technologically feasible process is developed for its conversion to fuels, at l Read More

This review highlights our studies of the nature of the true catalytic species in the Heck coupling of bromobenzene and styrene with conventionally prepared SiO2-supported Pd particles. Approaches including kinetic test, filtration test and catalyst poisoning were used to probe the behavior and nature of the possible active Pd species in combination with transmission electron microscopy and elemental analysis. We found that the Read More

Aromatic substitutions are a very important class of reaction for both the fine chemical and pharmaceutical industries. The use of palladium as a catalyst for these types of reactions is common during the research stages of product development. Its desirable criteria include high selectivity, being compatible with many types of functional groups, typical use without protection groups and strong bases, and introduction at relat Read More

The structural and synthetic aspects related to α-oxyiminophosphorus derivatives are reviewed. This includes their preparation through reactions involving C-N double bond or P-C single bond formation as well as the O-functionalization or transformations at the phosphorus atom of other phosphorus substituted oximes. Moreover the synthetic features of α-oxyiminophosphorus derivatives include the reduction of the oxim Read More

As steric repulsion, the electronic effect of catalysts also plays a crucial role in asymmetric catalysis. The influence of the electronic effect of catalysts on the enantioselectivity in asymmetric catalysis, including metal-chiral ligand complex and organocatalyst systems, was reviewed. The applicability and complexity of the influence were discussed. Rationally tuning the electronic effect of catalysts can indeed improve enan Read More