Current Organic Synthesis - Volume 7, Issue 5, 2010

From the organic synthesis point of view, major reviews concerning the uses and applications of the trifluoromethyl group in chemistry appeared in the 90's by Kiselyov [1] and McClinton [2]. Despite fluorine atoms are extremely rare in natural compounds, they have a valuable importance in drug synthesis and agrochemicals. Particularly, the trifluoromethyl group is very common in drug compounds (i.e marketed pharmaceut Read More

This paper reviews the recent findings on trifluoromethylation of carbonyl compounds. Emphasis was given to the description of the trifluoromethylating agents, their activation mode, their reaction with carbonyl compounds, as well as applications in organic synthesis.

This review covers the trifluoroacetylation reaction in organic synthesis and its importance for the construction of trifluoromethylated compounds. Developed reagents for trifluoroacetylation are described, as well as their characteristics and preparation, giving emphasis on their applications and limitations in organic synthesis. Trifluoroacetylation, although commonly employed for the protection of functional groups (amines, Read More

Development of efficient routes to many kinds of fluorine-containing heterocycles is an attractive area of research since these compounds are now widely recognized as important organic materials for their potential use in medicinal and agricultural scientific fields. This review survey research works on trifluoromethyl- substituted fused bicyclic heterocycles and their corresponding benzo-fused analogues over the last ten years. Read More

Stereoselective synthetic methods for the construction of the tertiary or quaternary asymmetric carbon centers having a trifluoromethyl group and carbon substituent(s) or hydrogen atom, not heteroatom substituent(s), are described.

The literature concerning amination of electron rich arenes with azodiesters using catalytic amount of Lewis acids as ZnI2, ZnCl2, CF3SO3H or CF3COOH and reports focused on application of diprotected hydrazine derivatives as versatile intermediates in the synthesis of several important compounds are reviewed. The reports concerning reactions of different olefins with diethyl azodicarboxylate (DEAD) and 4-phenyl-1,2,4- Read More

Since past few decades, Room Temperature Ionic Liquids (RTILs) have extensively been used in organic synthesis as solvents, catalysts and catalyst/solvents in chemical as well as enzymatic reactions, whereas their interest in various different branches of science is expanding exponentially. RTILs show an enhanced performance in a number of syntheses involving carbohydrates when compared to the conventi Read More