Current Organic Synthesis - Volume 7, Issue 2, 2010

Over the last several years the need to improve efficiency and minimize waste has spurred chemists to develop new catalysts for a wider range of reactions that was previously only achievable using stoichiometric reagents. A very powerful approach at achieving this goal is through the use of multiple transition metal catalysed one-pot processes, whereby the desired target compound is synthesised in a single work-up step. In t Read More

Since the period of the 1940's, 2-aminopropane-1,3-diol (“serinol”) and its commercial C-substituted analogous are a popular motif in organic compounds covering almost all facets of organic synthesis. This first part of the review deals mainly with the nowadays approaches focused on serinols'reactivity with carbonyl electrophiles (aldehydes and ketones) as well as its applications.

This brief review article describes the progress made in the synthesis of five- and six-membered heterocyclic rings by the application of the ring-closing metathesis reactions during the period of 2007-2008.

Increasing emphasis has been placed on producing synthetic organic compounds faster and more efficiently than can be produced using conventional methodology. It is often observed that tried and true methods for performing synthesis, work-up, and purification on individual or low number of reactions do not scale up well even to a modest level of parallel synthesis. As a result, novel methodologies or parallel and co Read More