Current Organic Synthesis - Volume 7, Issue 3, 2010

Recent advances via internal and external asymmetric induction in the asymmetric Pictet-Spengler reaction employed in the synthesis of indole alkaloids are described. Mechanistic studies on the diastereoselectivity, important reaction intermediates, possible mechanisms of the cis to trans isomerization, as well as recent organocatalytic approaches have been highlighted.

Structure and function of synthetic amino acids with side chain metal complexes have particular importance for extending our understanding of organometallic compounds under physiological conditions and mimic protein folding and stabilization. Chemists are now designing biomimetic organo-metallic amino acids that can form both secondary and tertiary structures. An overview of the design and synthesis of non-prote Read More

The second part of the review aims at describing the modern serinols based challenges for organic chemists interested in stereoselective transformations, total and iterative synthesis with current highly applied (bio)impact.

The articles which report about the synthesis of chroman-4-ones by hydrogenation/reduction of the corresponding chromones are reviewed. The following methods of synthesis are reviewed: hydrogenation over palladium, platinum, Raney-nickel, catalytic transfer hydrogenation, homogeneous hydrogenation, reduction by complex hydrides, by DIBALH and some special methods. For every appropriate reaction yiel Read More