Current Organic Synthesis - Volume 6, Issue 4, 2009

Catalytic oxidation reactions in ionic liquids using H2O2 as oxidant are reviewed and transition metal catalysts as well as metal-free catalysts are considered. Different ionic liquids, catalyst systems and substrates are compared. The surveyed reactions comprise the oxidation of alcohols, aromatic aldehydes and ketones, oximes, alkanes, benzene and sulfur compounds, Baeyer-Villiger oxidation, epoxidation and dihydroxyl Read More

Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.

In continuation to our earlier review, we report herein further development on the organocatalytic approach for the synthesis of enantioenriched organic compounds. Application of synthetic bifunctional chiral organocatalysts with emphasis on Brønsted acid catalyst derived from chiral phosphoric acid derivative, and mechanism of asymmetric catalysis are discussed.

Carbohydrate-protein interactions play a major-role in recognition of cells by external macromolecules. Single saccharide ligands, however, bind only weakly to their protein receptors. Sufficient affinity is achieved by appropriate mutual orientation of the saccharide epitopes and their protein receptors, which allows multiple simultaneous interactions. Solid-supported methods allowing synthesis of multiantennary glycoconjugat Read More

The use of bismuth(III) salts in organic synthesis has attracted an increasing interest over the last years. Systems comprising of bismuth(III) salts are generally catalytic and involve a relatively non-toxic metal. These features are of great interest in the area of green and pharmaceutical chemistry. Due to the fact a large number of natural compounds and known drugs are heterocycles, their construction and/or functional Read More