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- Volume 6, Issue 1, 2009
Current Organic Synthesis - Volume 6, Issue 1, 2009
Volume 6, Issue 1, 2009
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Modulation of Enzymes Selectivity Via Immobilization
More LessEnzymes are very versatile catalysts in organic chemistry, although in many occasions they present very low selectivity towards non-natural or artificial compounds. A simple strategy has recently been discovered which allows a greater enhancement of the enzyme selectivity. This strategy -based on the conformational changes of these enzymes during catalysis- consists in the preparation of a biocatalysts library using differ Read More
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Enantioselective Enzyme-Catalysed Synthesis of Cyanohydrins
Authors: Jarle Holt and Ulf HanefeldCyanohydrins are valuable intermediates in organic synthesis. They enable an extensive chemistry that can be implemented starting either from the nitrile or from the hydroxy functionality. A number of challenges relevant to the enzyme-catalysed synthesis of chiral cyanohydrins have been addressed in recent years. In this review we will discuss three topics: (1) The enantioselective synthesis of cyanohydrins catalysed by Hy Read More
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C2-Symmetric Pyrrolidines Derived from Tartaric Acids: Versatile Chiral Building Blocks for Total Synthesis, Catalyst Design, Supramolecular and Medicinal Chemistry
Authors: Andreas Blum and Wibke E. DiederichChiral 3,4-difunctionalized pyrrolidines, which can be derived from L-(+)- and D-(-)-tartaric acids, are useful and versatile building blocks in total synthesis, catalyst preparation as well as supramolecular and medicinal chemistry. The preparation of these azacycles, possible transformations and their application are described herein.
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Synthesis of 3-Arylpropenal and 3-Arylpropionic Acids by Palladium Catalysed Heck Coupling Reactions: Scopes and Limitations
Authors: Laurent Djakovitch and Catherine PinelSeveral classical methods were described for the selective synthesis of cinnamaldehyde derivatives and 3-arylpropionic acids but their applicability remains limited due to the difficult and costly synthesis of the starting materials. Since few years, palladium catalyzed procedure has been reported. Whatever they use homogeneous or heterogeneous palladium catalysts, these catalytic methods offer viable environmental fr Read More
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Rational Approaches to Organic Ferromagnets Based on Neutral Radicals Appended to Organosulfur Donors
Authors: A. Alberola and M. PilkingtonThe science of molecule-based materials is an exciting subject in light of its fundamental scientific interest and potential applications. Considerable efforts are now being invested in developing strategies for the design and preparation of new materials involving an interplay or synergy between electrical conductivity and magnetic properties. This review examines approaches for the preparation of organic conducting ferromagn Read More
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Recent Development about the Use of Pyrocarbonates as Activator in Organic Synthesis: A Review
Authors: Renato Dalpozzo, Giuseppe Bartoli, Marcella Bosco, Paolo Melchiorre and Letizia SambriIn the last years, the use of pyrocarbonates and particularly di-tert-butyldicarbonate (Boc2O) has found a renaissance in organic synthesis. Together with the classical couple Boc2O/DMAP, new synthetic strategies have been developed in the presence of environmentally benign Lewis Acids. So new syntheses of protected Boc-amines and alcohols have appeared in literature. Moreover, the use as activator in the synthe Read More
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Volumes & issues
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Volume 22 (2025)
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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