Current Organic Synthesis - Volume 6, Issue 2, 2009

Chiral non-racemic perazamacrocyles containing three or more nitrogen atoms in the form of different functions (amine, amide, imine) are prepared from optically active amines, diamines, α-aminoacids, and their derivatives, by properly selected methodologies. The many applications of these optically pure perazamacrocycles rely on the basic and/or hydrogen bond donor properties of the nitrogen functions and includ Read More

The formation of chiral non-racemic perazamacrocyles containing three or more nitrogen atoms in the form of identical of different functionalities can be achieved by diverse methodologies which usually exploit the sequential formation of carbon-nitrogen bonds by reaction of nucleophilic nitrogen functions with electrophilic compounds. The rigidity and restricted flexibility of the reaction partners is generally a requisite for Read More

The ubiquity of piperazine-2,5-dione core (2,5-diketopiperazine, DKP) in biologically active natural products and the preponderance of its heterocyclic framework in many drugs, has encouraged the development of methods for the selective functionalisation of readily available piperazine-2,5-dione precursors. C-functionalisation using DKPs as electrophilic glycine templates is generally mediated by N-acyliminiu Read More

In recent years the development of transition metal complexes having in its structure pincer type ligands has received considerable attention. Nowadays these complexes are designed and synthesized not just for the mere structural interest but for the great number of potential applications these compounds may have. Thus, the present paper presents and discusses recent advances (covering until early 2008) o Read More

The Pschorr reaction is a classical ring closure process for the formation of polycyclic systems in which two aryl moieties are joined together. It represents a bridge that connects diazonium ion chemistry with PAH synthesis. The Pschorr reaction has been employed as a key step in a number of carbocyclic and heterocyclic ring forming transformations for the synthesis of complex polycyclic molecules. Our continuing interest i Read More

The use of fluoride ion as a base and nucleophile has been widely exploited in organic synthesis. On the other hand over the last few decades the fast-growing development of polymer supported reagents has led to the synthesis of a variety of fluorides on solid support. Such compounds display some major benefits: i.e they are less hygroscopic, easy to recover and to recycle. Tetraalkylammonium fluorides represent som Read More