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- ISSN: 1570-1794
- E-ISSN: 1875-6271
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Biocatalysis in the Preparation of the Statin Side Chain
- Source: Current Organic Synthesis, Volume 6, Issue 4, Nov 2009, p. 362 - 379
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- 01 Nov 2009
Abstract
Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
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