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2000
Volume 6, Issue 1
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Cyanohydrins are valuable intermediates in organic synthesis. They enable an extensive chemistry that can be implemented starting either from the nitrile or from the hydroxy functionality. A number of challenges relevant to the enzyme-catalysed synthesis of chiral cyanohydrins have been addressed in recent years. In this review we will discuss three topics: (1) The enantioselective synthesis of cyanohydrins catalysed by Hydroxynitrile Lyases (Oxynitrilases); (2) The preparation of enantiopure cyanohydrins catalysed by hydrolases/ lipases via (dynamic) kinetic resolutions and (3) the (in situ) conversion of the enantiopure cyanohydrins, extending the use of cyanohydrins as building blocks in organic synthesis.

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/content/journals/cos/10.2174/157017909787314858
2009-02-01
2025-07-09
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/content/journals/cos/10.2174/157017909787314858
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