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- Volume 15, Issue 8, 2018
Current Organic Synthesis - Volume 15, Issue 8, 2018
Volume 15, Issue 8, 2018
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1,4-Dithiane-2,5-diol: A Versatile Synthon for the Synthesis of Sulfur-containing Heterocycles
Background: 1,4-Dithiane-2,5-diol (1,4-DTD) is the stable dimer of α-mercapto acetaldehyde. This commercially available ambidentade compound is characterized as having in its chemical structure one group that acts as an electrophile and another that acts as a nucleophile, this permits its use as versatile and efficient synthon in synthetic heterocycle procedures. Objective: The aim of this review is to present synthetic applic Read More
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Recent Advances in Three-Component Cyclocondensation of Dimedone with Aldehydes and Malononitrile for Construction of Tetrahydrobenzo[b]pyrans Using Organocatalysts
More LessBackground: The majority of naturally occurring compounds, pharmaceuticals, and drug-candidate molecules possess heterocyclic scaffolds. In this context, tetrahydobenzo[b]pyrans are of considerable importance. In the line with the synthesis of these valuable heterocyclic compounds, the researchers tried to synthesize these molecules using different organocatalysts. The development of new strategies for three-compone Read More
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Hydrotalcites in Organic Synthesis: Multicomponent Reactions
Authors: Eliana Nope, Gabriel Sathicq, José Martinez, Hugo Rojas, Rafael Luque and Gustavo RomanelliBackground: The use of solid bases as heterogeneous catalysts allows the replacement of conventional bases in Organic Chemistry, being of outmost importance. Lamellar double hydroxides or hydrotalcites are materials having excellent basic properties and high surface areas. As their surface properties have been used as bifunctional catalysts allowing the incorporation of metals and depending on the calcination temp Read More
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A Review on the Scope of TFDO-Mediated Oxidation in Organic Synthesis--Reactivity and Selectivity
Dioxiranes are three-membered strained ring peroxides that are typical archetype examples of electrophilic entities. A dioxirane-based oxidant named 3-methyl(trifluoromethyl)dioxirane (TFDO) is a fluorinated analogue of the extremely valuable oxidant dimethyldioxirane (DMDO). Owing to the strained threemembered ring and presence of electron-withdrawing trifluoromethyl group, TFDO is several times more reactive tha Read More
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1,3-Thiazolidin-4-ones: Biological Potential, History, Synthetic Development and Green Methodologies
Authors: Jonas da Silva Santos, Joel J. Junior and Flavia M. da SilvaBackground: We present here the synthesis of 1,3-thiazolidin-4-one (1) and its functionalised analogues, such as the classical isosteres, glitazone (1,3-thiazolidine-2,4-dione) (2), rhodanine (2-thioxo-1,3- thiazolidin-4-one) (3) and pseudothiohydantoin (2-imino-1,3-thiazolidin-4-one) (4) started in the midnineteenth century to the present day (1865-2018). Objective: The review focuses on the differences in the representation of the Read More
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Ionic Liquid Promoted Eco-friendly and Efficient Synthesis of Six-membered N-polyheterocycles
By Navjeet KaurBackground: The synthesis of N-polyheterocycles by environmentally benign method is highly attractive but challenging proposition. New strategies have been developed for the preparation of polycyclic heterocycles in the last decades. In this review article, the synthesis of nitrogen containing six-membered polycyclic heterocyclic compounds is presented with the application of ionic liquids. This contribution focuses on the litera Read More
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Highly Selective Gold-Catalyzed Cycloisomerization of Furanolabdanoid Dialkynes with Alkynyl Substituents in the Furan Ring
Authors: Yurii V. Kharitonov, Makhmut M. Shakirov and Elvira E. ShultsAim and Objective: We studied the synthesis of new groups of functionalized isobenzofurans and isoindolines by selective gold catalyzed cycloisomerization of some new optically active furandialkynes derived from the natural furanolabdanoid lambertianic acid. Functionalized isobenzofurans and isoindolines are considered as privileged structures that are currently experiencing a renewed interest in medicinal Read More
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Novel Chemical Method for Decreasing of Toxicity of Highly Cytotoxic Amidoximes by Introduction of Benzo[4,5]imidazo[2,1-b]thiazolyl Fragment
Authors: Edgars Abele, Ramona Abele, Lena Golomba, Ilona Domracheva, Tatjana Beresneva, Elina Jaschenko and Anita GulbeAims and Objectives: The aim of the research is to obtain and to investigate the cytotoxicity of a novel class of non-toxic oximes – derivatives of N-(benzo[4,5]imidazo[2,1-b]thiazol-3-ylmethoxy)-ω- (hetarylsulfanyl)-alkanamidines. Materials and Methods: To assess the possible toxicity of the compounds, acute oral LD50 was calculated. The calculations were based on tested compounds IC50 values in relation to 3T3 (mouse fi Read More
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Synthesis, Antimicrobial Evaluation of Some New 1, 3, 4-Thiadiazoles and 1, 3, 4-Thiadiazines
Authors: Ameen A. Abu-Hashem and Rasha A. M. FatyBackground: 1, 3, 4-thiadiazoles, 1, 3, 4-thiadiazines and thienopyrimidines have newly attracted attention due to their forceful pharmacological activities. They showed antimicrobial, antiviral, analgesic and anti-inflammatory properties. Objective: The aim of this research is to synthesize new thiadiazolothienopyrimidines (2-10), thienopyrimidothiadiazines (11-15), quinoxaline-thienopyrimidinones (16) and thienopyrimido- thiadi Read More
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Utility of Diketone in Heterocyclic Synthesis: Synthesis of New Substituted Pyrimidines and Fused Pyrimidine of Potential Biosignificant Interest
Authors: Mohamed A.M.A. Reheim, Ibrahim S.A. Hafiz and Hend S.E.A. RadyAim and Objective: In this study, a new series of iminopyrimidine derivatives were synthesized from the reaction of the key intermediate 2-imino-6-phenyl-2,3-dihydropyrimidin-4(5H)-one 4 with a variety of electrophilic and nucleophilic reagents under a variety of mild conditions. The structures of the newly synthesized compounds were characterized on the basis of their elemental analysis and spectroscopic data. The antimicrob Read More
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Diphenyl Diselenide – catalyzed Reductive Coupling of Nitroarenes to Aromatic Azo and Azoxy Compounds with Sodium Borohydride in Alkaline Ethanol
Authors: Nadjah Belattar, Samir Benayache and Fadila BenayacheAim and Objective: A simple catalytic method has been developed to achieve the reduction of nitroarenes with NaBH4 using diphenyl diselenide catalyst in order to obtain the azoxyarene, azoarene products under mild conditions. Materials and Methods: The reduction of different substituted nitroarenes was realized in alkaline ethanolic solution using mild sodium borohydride in the presence of diphenyl diselenide as an electro Read More
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Volumes & issues
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Volume 22 (2025)
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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