Current Organic Synthesis - Volume 15, Issue 3, 2018

Background: The chemists have been interested in light as an energy source to induce chemical reactions since the beginning of the scientific chemistry. This review summarizes the chemistry of photochemical reactions with emphasis of their synthetic applications. The organic photochemical reactions avoid the polluting or toxic reagents and therefore offer perspectives for sustainable processes and green che Read More

Background: In recent years, the development and diversification of heterocyclic compounds has become central to the discovery of bioactive compounds with novel or improved pharmacological properties. In particular, N-containing heterocycles are proved to be promising leads and drug candidates, and received huge attention of the medicinal chemists. Objective: Many drugs especially antibiotics are becoming obsolete Read More

Background: Xanthene is pharmacologically important oxygen containing heterocyclic moeity exhibiting an array of potent biological activities like antibacterial, antiviral, antiinflammatory, antitumor, antioxidant, antiplasmodial etc. Other useful applications of these heterocycles are as fluorescent materials for the visualization of biomolecules and in laser technology. Objective: This review gives an insight of the literatur Read More

Aim and Objective: Although many synthetic methods are known for seven-membered N,Oheterocycles, most of them focus on fused benzoxazepines. In fact, an exhaustive searching of the literature revealed that very few synthetic approaches for non-fused 1,4-oxazepanes have been reported. Thus, straightforward and efficient synthetic strategies for the construction of diversely substituted 1,4-oxazepanes woul Read More

Aim and Objective: Pyrazolone sulfones have been reported to exhibit herbicidal and antibacterial activities. In spite of their good bioactivities, only a few methods have been developed to prepare pyrazolone sulfones. However, the substrate scope of these methods is limited. Moreover, the direct sulfonylation of pyrazolone by aryl sulfonyl chloride failed to give pyrazolone sulfones. Thus, developing a more efficient method t Read More

Background: Indolizine pharmacophore is known to exhibit various promising pharmacological properties such as analgesic, anticancer, antihistaminic, antidiabetic, anti-inflammatory, antileishmanic, antimicrobial, antimutagenic, antioxidant, antitubercular, antiviral, larvicidal and herbicidal activities. Objective: In the present investigation, it was envisaged to synthesize a series of novel ethyl-7-substituted-3-(4- subs Read More

Aim and Objective: Ceria loaded on solid zirconia was employed as heterogeneous catalyst for the synthesis of pyridine derivatives via a one-vessel, four-component reaction consisting of substituted aldehyde, malononitrile, dimethylacetylenedicarboxylate and dimethylaniline with good to excellent product yields (87 to 95%). The noteworthy advantages of the facile method with ethanol as solvent are excellent yields with s Read More

Background: The regioselective synthesis of spiro-heterocyclic compounds is intriguing since those compounds have unique non-planar structures and great potential for binding to biomolecules because of their inherent rigid chiral structure. A novel class of furanone and spiro-heterocyclic derivatives were synthesized and evaluated for antifungal activities to establish structure-activity relationship (SAR). Results: The synthes Read More

Aims and Objective: A series of novel phthalazine derivatives was synthesized with versatile, readily accessible electrophilic and nucleophilic reagents. The newly synthesized compounds were confirmed by the results of spectroscopic measurements. Hence, their potential clinical application investigated in particular for cancer treatment. Materials and Methods: The newly synthesized compounds were characterize Read More

Background: The Cruciferous family of vegetables which includes Brassica Turnips showed antioxidant and hepatoprotective effects. The phytochemical investigations of the aerial parts of the traditional Japanese turnip vegetable (B. rapa L. 'hidabeni') revealed the presence of three chalcone glycosides, along with other glycoside components. As many natural products inhibited Ag-stimulated degranulation in cellular Read More

Aim and Objective: The use of glycosyloxymethylfurfural (GMF), the dehydration product of isomaltulose, in the one-step multicomponent aza-Morita-Baylis-Hillman (aza-MBH) reaction, was studied. Materials and Methods: The reaction conditions and scope were investigated with respect to solvent, combinations of catalysts (Lewis acids and nucleophilic base), and the nature of the amine and the acrylic partners. Results: The Read More