Current Organic Synthesis - Volume 15, Issue 6, 2018

Background: 2,3-Benzodiazepines represent an important class of biologically active compounds, some members of this family have reached the human clinical stage. With formal bioisosteric replacement of the benzene ring to five-membered nitrogen heterocycles, several new diazepine and 1,2,5-triazepine derivatives have been synthesized in the past 30 years. Objective: Investigations in the field of heterocyclic chemistry is Read More

The chemical modifications of proteins or protein complexes have been a challenging but fruitful task in the post-genomic era. Bioorthogonal reactions play an important role for the purpose of selective functionalization, localization, and labeling of proteins with natural or non-natural structures. Among these reactions, reductive amination stands out as one of the typical bioorthogonal reactions with high efficiency, go Read More

Background: Transition metal catalysts are becoming increasingly more important in organic synthesis and are being used to catalyze novel reactions that allow for more efficient synthesis of many pharmaceuticals. Transition metal-catalyzed reactions of 3-aza-2-oxabicyco[2.2.1]hept-5-enes provide efficient synthetic pathways to generate a diverse range of biologically and synthetically useful products. 3-Aza-2- oxabicyc Read More

Background: C-H activation has attracted great interests over the past two decades, which resulted in an explosive growth in both quality and quantity of published papers related to this topic. Objective: In this review, a bibliometric analysis was performed to evaluate the publications in this field from 1996 to 2015 based on the Science Citation Index (SCI) Expanded database. This work presented a detailed overview of C-H a Read More

Background: Quinazolines, the important group of benzodiazines, are widely known in medicinal chemistry due to their broad spectrum of biological activities. Notably, extensive research on the synthesis and application of quinazoline derivatives for electronic devices, luminescent elements, photoelectric conversion elements, and image sensors has been published recently. Objective: This review reports luminescent small mo Read More

Background: I2/DMSO oxidative system catalyzed reactions have received considerable attention because they represent the advantages of being greener, efficient, atom-economical, low-cost, with mild conditions and ecofriendliness that meet with the requirements of sustainable chemistry. In recent times, the I2/DMSO oxidative system has been successfully applied in different types of organic reactions. Objective: The aim of t Read More

Background: N-phthalimide amino acid hydrazide is a class of compounds that have the potential therapeutic use. In general, hydrazinolysis of N-substituted amino acid(s) ester removes the ester group and yields the corresponding hydrazide. However, in case if N-substitution group is phthalimide, phthalimide group is cleaved and not the ester group. The resulted compound, therefore, is amino acid ester rather than N Read More

Background: Acridine and quinoline derivatives have a wide range of biological activities such as antioxidant and antitumor where quinoline derivatives intercalate between base pairs of double-stranded DNA through π-π interactions. Therefore, the development of new compounds with antitumor activity could be an important therapeutic strategy against this metabolic syndrome. Objective: This study was undertaken to Read More

Aim and Objective: The efficient synthesis of disaccharide containing iminosugar moiety has a considerable interest in the field of glycoscience. In the present work, we describe a novel and applicable method for synthesis of five and six-membered N-substituted iminosugars attached with sugar moiety (pseudodisaccharides). Materials and Methods: The method of the glycosylation was based on the coupling of iminosugar t Read More

Aim and Objective: We reported in this manuscript, synthesis of novel pyrazolopyrazinothienopyrimidines. The o-amino-thienopyrazolopyrazine-carbonitrile 4 was used as a versatile precursor for synthesis of new heterocyclic compounds. Due to development of resistance to the current antimicrobial therapy and non-steroidal anti-inflammatory drugs (NSAIDs), continues research for more effective agents is interesting. H Read More

Aim and Objective: Chromene scaffold is one of the most famous oxygen heterocycles that have widely found in plants playing pivotal roles in medicinal and synthetic chemistry. This study was undertaken to provide a green protocol for the synthesis of novel functionalized chromen-pyrrole hybrids by a regioselective three-component reaction via both conventional and sonochemical methods. Because of fascinating features Read More