Current Organic Synthesis - Volume 15, Issue 4, 2018

Background: Pericyclic reactions characterized by a cyclic transition state, have been established as a dominant approach for the synthesis of heterocyclic scaffolds owing to their tremendous efficacy, regioselectivity, and enantioselectivity. Pericyclic chemistry is a promising and creative route to various biologically significant five and six membered oxygen or nitrogen ring systems. Recognizing the reaction's potential, syn Read More

Background: Although the chemistry of heteroaromatic monoamino azoles has been surveyed more than once in the last decade, the chemistry of the di- and triaminoazoles has not been reviewed. In this article we will survey the synthesis, chemistry and utility of the diaminoazoles. In this review, the chemistry of the diaminoazoles as well as their most important utilities will be surveyed. Objective: The review focuses on re Read More

Background: Increasing use of the three-membered ring in drug development initiates the search for efficient methods of transformations of cyclopropane derivatives. Oxidation of methylene group activated by an adjacent cyclopropane represents a direct approach towards carbonylcyclopropanes, allows avoiding unnecessary synthetic stages and meets the requirements of atom economy. Objective: In this r Read More

Aim and Objective: In this study, for the first time keplerate cluster [Cu20Cl(OH)24(H2O)12 (P8W48O184)]25- (hereafter [W48P8Cu20]) was supported on SMNP (Fe3O4-@SiO2) via amine functionality (ASMNP) as a magnetically-recoverable catalyst (hereafter [WPCu@ASMNP]). This nanocatalyst showed high activity for the synthesis of cyclic carbonates under solvent-free conditions. Materials and Methods: After prep Read More

Aim and Objective: The development of small molecules that can interact with key therapeutic target represents an active field of research. Therefore, new approaches for increasing the molecular diversity of a starting material, such as a natural product, are needed. Herein, the carbonyl group present on a pregnane scaffold, or easily obtained from the oxidation of the corresponding alcohol, was used to obtain a Read More

Aim and Objective: The aim of our work is to demonstrate catalytic application of our previously reported simple Cu(I) ion supported on weakly acidic polyacrylate resin for Azide-Alkyne cycloaddition (CuAAC), Azide-Nitrile cycloaddition and in synthesis of 1-azido-4-methoxybenzene. Material and Method: To investigate the catalytic ability of title Cu(I) catalyst we performed the reaction of different aryl azide with a broader spe Read More

Background: Ring opening metathesis polymerization of lactones using alkylidene catalysts is an alternative to obtain unsaturated linear polyesters with remarkable thermal and mechanical properties. Also, these polyesters have properties of biodegradability which opens up a wide range of applications as environmentally friendly thermoplastics and biomaterials. Objective: This research aims to present one route to obtain a Read More

Aim and Objective: Itopride is a prokinetic agent used for treating conditions like non-ulcer dyspepsia. Itopride is administered as its hydrochloride salt. Trimethobenzamide is used for treating nausea and vomiting and administered as its hydrochloride salt. The aim is to develop a novel and environmental friendly method for large-scale production of itopride and trimethobenzamide. Materials and Methods: Itopride and trime Read More