Current Organocatalysis - Online First

Introduction Aromatization of dithioacetal derivatives is essential for the synthesis of bioactive compounds and drug design, playing a key role in pharmaceuticals, agrochemicals, and materials science. This study explores the synthesis and catalytic application of Cu2O nano hollow arrays in ring-expansion aromatization reactions of cyclic dithioacetal derivatives obtained from cyclohexanones. Methods By using Cu2O nano h Read More

Background β-lactams have been primarily utilized as a leading class of effective antibiotics. They have been found to show activity against various diseases, prompting the scientific community to prioritise innovative protocols for their synthesis. The general and well-known synthetic strategy involves the classical Staudinger reaction exhibiting [2+2] cycloaddition reaction. However, the protocol utilizes stoichiometric excess of Read More

Introduction Herein, we have developed Zn(OTf)2-catalysed efficient cascade reaction for the synthesis of fully functionalized benzyl-pyrazolyl coumarin compounds using 4-hydroxy coumarin, ethyl acetoacetate, aryl aldehyde(s), and phenylhydrazine under mild conditions in a single pot for the first time. The reaction exhibits excellent reactivity, broad substrate applicability, and good functional group tolerance. Methods This Read More